血浊-脑浊-脑毒理论对阿尔茨海默病防治指导意义初探

Preliminary study on the guiding significance of turbid blood-turbid brain-brain toxicity theory in the prevention and treatment against Alzheimer’s disease

阿尔茨海默病(AD)的病因病机主要是肾亏髓减、脑浊内生、毒损脑络,证属本虚标实。结合中医理论基础和现代基础研究,拟初步探讨血浊-脑浊-脑毒理论体系对AD预防和治疗的指导意义。血浊是AD发病前的病理状态,脑浊-脑毒的具体表现之一是Aβ过量沉积与Tau蛋白过度磷酸化,Aβ沉积和Tau蛋白过度磷酸化对脑细胞和脑功能的损害即是毒损脑络的体现之一。脑络与西医中神经血管单元(NVU)的功能相似,脑络受损,亦能增加脑浊-脑毒的生产,临床治疗当以益肾祛毒为主。

The etiology and pathogenesis of Alzheimer’s disease(AD)are mainly renal hypoplasia,brain turbidity endogenous,and brain damage caused by poison.Combining the theoretical foundation of traditional Chinese medicine with basic modern research,we intend to explore the guiding significance of the theory of turbid blood,turbid brain and brain toxicity in the prevention and treatment of AD.Turbid blood is a pathological state before the onset of AD.One of the specific manifestations of turbid brain-brain toxicity is the excessive deposition of Aβ and hyperphosphorylation of Tau protein,and naoluo refers to the neurovascular unit(NVU);Aβ and Tau protein,are toxic to the brain;at the same time,naoluo damage can also increase the production of turbid blood-brain toxicity.Clinical treatment methods should be based on Yishen Qudu.