左西孟旦联合BiPAP无创通气在重症心力衰竭治疗中的应用

Application of levosimendan combined with BiPAP non-invasive ventilation in the treatment of patients with severe heart failure

目的:探讨左西孟旦联合双水平气道内正压(BiPAP)无创通气对重症心力衰竭的治疗效果。方法:将80例重症心力衰竭患者分为观察组和对照组各40例。观察组采用左西孟旦联合BiPAP无创通气治疗;对照组采用BiPAP无创通气治疗。比较两组治疗前、治疗7 d后血气指标、心功能指标。结果:治疗7 d后,两组PaO_(2)、SV、LVEF均较治疗前升高,PaCO_(2)、NT-proBNP均较治疗降低,且观察组优于对照组(P<0.05)。结论:重症心力衰竭采用左西孟旦联合BiPAP无创通气治疗可以改善血气指标及心功能指标,减轻心力衰竭程度。

Objective:To explore the effect of levosimendan combined with bi-level positive airway pressure(BiPAP)non-invasive ventilation on patients with severe heart failure.Methods:Eighty patients with severe heart failure were divided into an observation group and a control group with 40 cases each based on the random number table method.The observation group was treated with levosimendan combined with BiPAP non-invasive ventilation while the control group only with BiPAP non-invasive ventilation.The blood gas indexes and cardiac function were compared between the two groups before and 7 days after treatment.Results:The levels of alveolar oxygen partial pressure(PaO_(2)),stroke volume(SV),and left ventricular ejection fraction(LVEF)were risen while the levels of arterial blood carbon dioxide partial pressure(PaCO_(2))and N-terminal probrain natriuretic peptide(NT-proBNP)were lowered 7 days after treatment than before in the two groups(P<0.05),and these data were much better in the observation group than the control group.Conclusion:Levosimendan combined with BiPAP non-invasive ventilation therapy for the treatment of patients with severe heart failure can improve blood gas index and cardiac function and reduce the degree of heart failure.