摘要
中药抗炎在近年来已成为一个重要的研究领域,中药制剂的抗炎临床研究已经取得了一定进展,但具体活性成分及作用机制仍需进一步明确。斑马鱼由于其独特的生物学优势,目前已被广泛应用于中药抗炎活性的筛选。综合近年来国内外有关斑马鱼模型在中药抗炎领域的报道,从已构建的斑马鱼炎症模型、斑马鱼模型中的炎症介质、斑马鱼模型在中药抗炎药物筛选中的应用3个方面对斑马鱼炎症模型及其在中药抗炎领域的研究进展进行综述,以期为模式生物斑马鱼在中药抗炎领域的研究应用提供新思路,为抗炎中药的开发与利用提供借鉴参考。
The anti-inflammatory properties of traditional Chinese medicine have become an important research area in recent years.At present,the anti-inflammatory clinical research of traditional Chinese medicine has made some progress,but the active ingredient and specific mechanism still needs to be further clarified.Due to its unique biological advantages,zebrafish has been widely used in the anti-inflammatory field of traditional Chinese medicine.This review synthesizes domestic and foreign reports on zebrafish models in the anti-inflammatory field of traditional Chinese medicine in recent years,and comprehensively reviews the recent advances of zebrafish models in this field from three aspects:the first one is different inflammation models of zebrafish,the second one is mediators of inflammation in zebrafish,and the last one is application of zebrafish in screening of anti-inflammatory drugs in traditional Chinese medicine.It will provide a new idea for the application of zebrafish in the anti-inflammatory field of traditional Chinese medicine and a reference for development and utilization of anti-inflammatory Chinese medicine.
作者
段秀英
马瑞娇
张云
刘可春
DUAN Xiuying;MA Ruijiao;ZHANG Yun;LIU Kechun(Biology Institute,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250103,China;Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province,Jinan 250103,China)
出处
《药物评价研究》
CAS
2021年第8期1573-1580,共8页
Drug Evaluation Research
基金
国家重点研发计划(2018YFC1707300)
齐鲁工业大学(山东省科学院)科教产融合创新试点工程项目(2020KJC-ZD08)
济南市“高校20条”资助项目(2020GXRC053)。
关键词
斑马鱼
转基因
炎症模型
炎症介质
中药
抗炎
药物筛选
zebrafish
transgene
inflammatory model
inflammatory mediators
traditional Chinese medicine
anti-inflammation
drug screening
