乳腺癌超声特征和ER、PR、CerbB-2、Ki-67阳性表达的相关性研究

Relationship between ultrasound features and expression of ER,PR,CerbB-2 and Ki-67 in breast cancer

目的分析乳腺癌患者的超声影像学特征及其和雌激素受体(estrogen receptor, ER)、孕激素受体(progesterone receptor, PR)、人表皮生长因子受体2(human epidermal growth factor receptor 2,CerbB-2)、增殖细胞核抗原(Ki-67)阳性表达的关系,为临床制定治疗方案提供参考依据。方法筛选出绍兴市人民医院2020年1-12月收治的80例乳腺癌患者作为研究对象,所有患者均行乳腺超声检查与ER、PR、CerbB-2、Ki-67检测,分析超声影像学特征与ER、PR、CerbB-2、Ki-67的检测结果,应用Pearson相关性分析法探讨超声影像学特征和ER、PR、CerbB-2、Ki-67阳性表达的关系。结果 29例病灶直径≤2 cm;23例病灶形态规则;35例病灶边缘光整;36例病灶边界清晰;65例内部回声呈低回声或混合回声;50例后方衰减;51例血供丰富;24例纵横比≤1;41例微小钙化;41例淋巴结转移。乳腺癌患者的ER、PR、CerbB-2、Ki-67阳性率分别为60.00%、56.25%、48.75%、77.50%。病灶边缘、病灶边界、后方衰减、淋巴结转移与ER呈正相关(r=0.251、0.303、0.213、0.308,均P<0.05);病灶边缘、淋巴结转移与PR呈正相关(r=0.065、0.387,均P<0.05);血供、淋巴结转移与CerbB-2呈正相关(r=0.184、0.376,均P<0.05),微小钙化与CerbB-2呈负相关(r=-0.023,P<0.05);病灶直径与Ki-67呈正相关(r=0.258,P<0.05)。结论乳腺癌超声特征和ER、PR、CerbB-2、Ki-67阳性表达之间存在明显的相关性。

Objective To analyse the ultrasonographic features of breast cancer patients and their relationship with estrogen receptor(ER),progesterone receptor(PR),CerbB-2 and Ki-67 positive expression so as to provide reference for clinical treatment plan.Methods Eighty cases of breast cancer patients in our hospital from January to December 2020 were selected as the research objects.All patients underwent breast ultrasound examination.ER,PR,CerbB-2 and Ki-67 were detected.Pearson correlation analysis was used to explore the relationship between ultrasound imaging characteristics and ER,PR,CerbB-2 and Ki-67 positive expression.Results A total of 29 cases had a tumor diameter≤2 cm,23 cases had regular shape,35 cases had smooth edges,36 cases had clear boundaries,65 cases had hypoechoic or mixed echo,50 cases had posterior attenuation,51 cases had rich blood supply,and 24 cases had an aspect ratio≤1.A total of 41 cases had microcalcification,and 41 cases had lymph node metastasis.The positive rates of ER,PR,CerbB-2 and Ki-67 in breast cancer patients were 60.00%,56.25%,48.75%and 77.50%,respectively.The edge,border,posterior attenuation and lymph node metastasis were positively correlated with ER(r=0.251,0.303,0.213,0.308,all P<0.05).The edge of lesion and lymph node metastasis were positively correlated with PR(r=0.065,0.387,all P<0.05).Blood supply and lymph node metastasis were positively correlated with CerbB-2(r=0.184,0.376,all P<0.05).Microcalcification was negatively correlated with CerbB-2(r=-0.023,P<0.05).The diameter of lesion was positively correlated with Ki-67(r=0.258,P<0.05).Conclusion A certain correlation exists between the ultrasound characteristics of breast cancer and the positive expression of ER,PR,CerbB-2 and Ki-67.