摘要
调节性坏死是新发现的新型细胞死亡途径,包括程序性坏死、细胞焦亡、铁死亡等。有研究报道,调节性坏死在缺血/再灌注、顺铂等药物、横纹肌溶解所诱发的急性肾损伤(AKI)中起到关键作用。研究调节性坏死相关通路在AKI中的作用,有望为明确AKI的发病机制及治疗提供新方向,具有潜在治疗和应用前景。本文对程序性坏死、细胞焦亡、铁死亡的相关信号通路及其在AKI中的相关研究进展进行综述,以期为AKI的防治提供潜在靶点。
Regulated necrosis is a newly discovered new cell death pathway,including necroptosis,pyroptosis and ferroptosis.It has been reported to play a key role in acute kidney injury(AKI)induced by ischemia/reperfusion,cisplatin and other drugs,and rhabdomyolysis.Studying the role of regulated necrosis-related pathways in AKI is expected to provide a new direction for clarifying the pathogenesis and treatment of AKI,with potential therapy and application prospects.In this review,we summarize the related signaling pathways of necroptosis,pyroptosis and ferroptosis,and the related research progress in AKI,in order to provide potential targets for the prevention and treatment of AKI.
作者
陆怡
周芳芳
罗群
Lu Yi;Zhou Fangfang;Luo Qun(School of Medicine,Ningbo University,Ningbo 315000,Zhejiang,China;Department of Nephrology,Hwa Mei Hospital,University of Chinese Academy of Sciences,Ningbo 315000,Zhejiang,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2021年第7期885-888,共4页
Chinese Critical Care Medicine
基金
浙江省医药卫生科技计划(2019KY181)
浙江省宁波市自然科学基金(2018A610299)。
