雌-孕激素序贯治疗对药物流产患者卵巢功能的影响

Effects of estrogen-progesterone sequential therapy on ovarian function in patients with medical abortion

目的研究雌-孕激素序贯治疗对药物流产患者卵巢功能的影响。方法选取药物流产患者110例,数字表法随机分为对照组(n=55)和观察组(n=55)。对照组行消炎、止血及抗感染等常规治疗,观察组在此基础上行雌-孕激素序贯治疗。比较两组临床指标变化,分析两组治疗前后卵巢功能[血清雌二醇(E2)、孕酮(P)],对比两组不良反应。结果观察组阴道出血时间、月经复潮时间均低于对照组(P<0.05),子宫内膜厚度高于对照组(P<0.05),月经持续时间与对照组比较差异无统计学意义(P>0.05)。两组治疗后E2水平较治疗前升高(P<0.05),P水平较治疗前降低(P<0.05);观察组治疗后E2水平高于对照组(P<0.05),P水平低于对照组(P<0.05)。观察组治疗后不良反应发生率为3.62%,与对照组的5.43%比较差异无统计学意义(P>0.05)。结论雌-孕激素序贯治疗可降低药物流产患者阴道出血量,缩短阴道出血时间,恢复卵巢功能,促进月经复潮,降低血管生成因子,且有一定用药安全性,值得推广。

Objective To study the effect of estrogen-progesterone sequential therapy on ovarian function in patients with medical abortion.Methods A total of 110 medical abortion patients were selected and randomly divided into control group(n=55)and observation group(n=55)by the digital table method.The control group received conventional treatments such as anti-inflammatory,hemostasis and anti-infection treatment;and the observation group received estrogen-progesterone sequential treatment on this basis.The changes of clinical indicators,including serum estradiol(E2)and progesterone(P),between the two groups were compared;so were the adverse reactions.Results The vaginal bleeding time and menstrual re-fluid time in observation group were significantly lower than those of the control group(P<0.05),and the endometrial thickness was significantly higher than that of the control group(P<0.05).There was no significant difference in menstrual duration compared with the control group(P>0.05).The E2 level of the two groups after treatment was significantly higher than before treatment(P<0.05),and the P level was significantly lower than before treatment(P<0.05).The E2 level of the observation group after treatment was significantly higher than that of the control group(P<0.05),and the P level was significantly lower than the control Group(P<0.05).The incidence of adverse reactions in the observation group after treatment was 3.62%,which was not statistically different from 5.43%in the control group(P>0.05).Conclusion Sequential treatment with estrogen and progesterone can reduce the amount of vaginal bleeding in patients with medical abortion,shorten the time of vaginal bleeding,restore ovarian function,promote menstrual reflux,reduce angiogenic factors,and has certain drug safety.