摘要
Robust evidence is needed for the hazardous effects of outdoor particulate matter(PM)on mortality and morbidity from all types of cancers.To summarize and meta-analyze the association between PM and cancer,published articles reporting associations between outdoor PM exposure and any type of cancer with individual outcome assessment that provided a risk estimate in cohort studies were identified via systematic searches.Of 3,256 records,47 studies covering 13 cancer sites(30 for lung cancer,12 for breast cancer,11 for other cancers)were included in the quantitative evaluation.The pooled relative risks(RRs)for lung cancer incidence or mortality associated with every 10-mg/m^(3) PM2.5 or PM10 were 1.16(95%confidence interval[CI],1.10–1.23;I2=81%)or 1.22(95%CI,1.02–1.45;I2=96%),respectively.Increased but non-significant risks were found for breast cancer.Other cancers were shown to be associated with PM exposure in some studies but not consistently and thus warrant further investigation.
基金
P.Y.,R.X.,and T.Y.were supported by China Scholarship Council funds(number 201906210065 for P.Y.,201806010405 for R.X.,and 201906320051 for T.Y.)
S.L.by an Early Career Fellowship of the Australian National Health and Medical Research Council(number APP1109193)
Y.G.by Career Development Fellowships of the Australian NationalHealth and Medical Research Council(numbers APP1107107 and APP1163693).
