摘要
金纳米颗粒(GNPs)由于具有独特的物理化学性质,近年来被广泛应用于生物医学领域的研究。放射性核素标记的GNPs可用于疾病的单模态和多模态分子成像,同时,利用所标记放射性核素自身的特点、GNPs自身的光热效应和放射增敏作用,或进一步负载治疗剂后,还可用于疾病的诊疗一体化。笔者对放射性核素标记的GNPs的制备及其在肿瘤诊疗中的研究进展进行综述。
Gold nanoparticles(GNPs)have been widely used in biomedical research in recent years due to their unique physical and chemical properties.Radionuclide-labeled GNPs can be used for single-model and multimodel molecular imaging of diseases.Furthermore,they can also be used for theranostics of diseases by utilizing the characteristics of the labeled radionuclide,the photothermal effect and radiosensitization of GNPs,or further loading therapeutic agents.This review mainly illustrates the preparation of radionuclide-labeled GNPs and their recent advances in the diagnosis and treatment of tumors.
作者
乔鹏鑫
兰晓莉
王宽垠
覃春霞
Qiao Pengxin;Lan Xiaoli;Wang Kuanyin;Qin Chunxia(Department of Nuclear Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Hubei Province Key Laboratory of Molecular Imaging,Wuhan 430022,China)
出处
《国际放射医学核医学杂志》
2021年第6期383-390,共8页
International Journal of Radiation Medicine and Nuclear Medicine
基金
国家自然科学基金项目(81873906、81401444)。
