"初免-吸引"免疫策略的研究进展

Research progress on"prime and pull"immunization strategy

"初免-吸引"免疫策略是指经胃肠外疫苗初次免疫后,通过局部使用T细胞引诱剂,在病原体进入的主要部位如生殖道、气道和肠道等招募和建立组织驻留记忆性T细胞,可应用到病毒或细菌等感染黏膜引起的疾病中,建立长期黏膜免疫。此文就该免疫策略在病毒、细菌、衣原体及螺旋体感染性疾病领域的研究进展进行综述,以期为疫苗研发提供新的思路。

The"prime and pull"immunization strategy refers to the recruitment and establishment of tissue resident memory T cells in the main regions of pathogen entry,such as reproductive tract,airway and intestine,through topical application of T cell attractants after the prime immunization of parenteral vaccines.This strategy can be applied to establish long-term mucosal immunity against diseases with mucosal infection from viruses,bacteria,etc.This article reviews the research progress of this immunization strategy in viral,bacterial,chlamydial and spirochetal infectious diseases,in order to provide new ideas for vaccine development.