获得性低磷骨软化症两例

Acquired hypophosphatemic osteomalacia:a report of two cases

低磷骨软化症是一种少见的代谢性骨病,按照病因分为遗传性、肿瘤性和获得性,通常表现为骨痛、骨折等,临床较少见,易误诊、漏诊。该文报道2例获得性低磷性骨软化症患者,分别为37岁的男性及33岁的女性,均以骨痛为主诉入院,明确低磷骨软化症后进一步查找病因,追查到1例为药物所致,另1例继发于原发性干燥综合征合并肾小管酸中毒,再对其临床特点、鉴别诊断及治疗进行分析以拓宽临床医师对该病的诊治思路。

Hypophosphatemic osteomalacia is a rare metabolic bone disease,which can be divided into the genetic,tumorous and acquired types according to the etiology.Clinical manifestations include bone pain and bone fracture,etc.It is likely to be misdiagnosed or miss diagnosis.In this article,we reported two cases(37-year-old male and 33-year-old female)of acquired hypophosphatemic osteomalacia.Two patients were admitted to our hospital due to chief complaint of bone pain.After the diagnosis of hypophosphatemic osteomalacia was confirmed,the cause of disease was further identified.One patient was diagnosed with medicine-induced hypophosphatemic osteomalacia.The other patient was diagnosed with hypophosphatemic osteomalacia secondary to Sjögren’s syndrome complicated with renal tubular acidosis.The clinical characteristics,differential diagnosis and treatment of two patients were subsequently analyzed,aiming to provide novel ideas for the diagnosis and treatment of acquired hypophosphatemic osteomalacia for the clinicians.