摘要
Accumulating evidence has revealed that the composition of gut microbiota in patients with diabetes mellitus(DM)varies compared to those with healthy controls.The abnormal production and releases of metabolites derived from microbiota into the blood circulation contribute to the development of DM through the activation of multiple metabolic pathways,including trimethylamine Noxide,short-chain fatty acids,lipopolysaccharide,aromatic amino acids,and their related metabolites.Therefore,the modulation of gut microbiota through dietary intervention,probiotics,broad-spectrum antibiotics,and fecal microbiota transplantation could be a potential therapeutic approach for DM.This review mainly summarized the complicated interactions of gut microbiota through its metabolites with DM.
基金
This work was supported by the Jiangsu Province Social Development Project(BE2018744)
the Project for Jiangsu Provincial Medical Talent(ZDRCA2016077)
the Fundamental Research Funds for the Central Universities(KYCX18-0182)
Joint Project of Southeast University and Pharmaceutical University of China(2242019K3DZ03)
Shenzhen Science&Technology Program(JCYJ20151029154245758,CKFW2016082915204709).
