阿片类毒品依赖者脱毒后中医体质实验室指标的差异性及相关性研究

Research on the Difference and Correlation of the Laboratory Indicators of TCMConstitution after Detoxification of Opioid Drug Addicts

目的:分析阿片类毒品依赖脱毒者中医体质分布情况,比较单一体质类型中前三种体质类型实验室指标的差异性和与体质的相关性。方法:对477名强制隔离戒毒人员进行中医体质分类及判定,收集单一体质类型中前三种体质类型人员的一般情况、吸毒相关信息、实验室指标,分析三种体质实验室指标的差异性及与体质的相关性。结果:阴虚质组丙氨酸氨基转移酶、γ-谷氨酰转肽酶、肌酐显著高于气虚质组(P<0.05),天冬氨酸氨基转移酶/丙氨酸氨基转移酶显著低于气虚质组(P<0.05)。多巴胺、肌酐与气虚质呈正相关[Exp(B)=1.022>1,P=0.046<0.05;Exp(B)=1.128>1,P=0.031<0.05],尿素与阴虚质呈负相关[Exp(B)=0.981<1,P=0.049<0.05]。结论:阿片类毒品依赖者脱毒者治疗时应根据其特点进行辨体施治,并注意观察阴虚质戒毒人员肝肾功的变化情况。多巴胺、肌酐与气虚质呈正相关,尿素与阴虚质呈负相关,在中医调体治疗时,应注意观察相应指标的变化情况。

Objective To analyze the distribution of traditional Chinese medicine(TCM)constitution of opioid drug addicts,and to compare the differences in laboratory indicators of the first three constitution types in a single constitution type and their correlation with constitution.Methods 477 compulsory isolation and detoxification personnel were classified and judged in TCM.The general conditions,drug-related information,and laboratory indicators of the first three constitution types in a single constitution type were collected,and the differences of the three kinds of constitution laboratory indicators and the correlation between constitution and laboratory indicators were analyzed.Result Alanine aminotransferase、γ-glutamyl transpeptadase、creatinine in the yin-deficiency constitution group were significantly higher than those in the qi-deficiency constitution group(P<0.05),and the aspartate aminotransferase/alanine aminotransferase of the yin-deficiency constitution group was significantly lower than that in the qi-deficiency constitution group(P<0.05);dopamine and creatinine were positively correlated with qi-deficiency constitution[Exp(B)=1.022>1,P=0.046<0.05;Exp(B)=1.128>1,P=0.031<0.05],while uric acid was negatively correlated with yin-deficiency constitution[Exp(B)=0.981<1,P=0.049<0.05].Conclusion The treatment of opioid drug addictsshould be based on their characteristics,and attention should be paid to the changes in liver and kidney function of the detoxification personnel with yin deficiencyconstitution.dopamine and creatinine are positively correlated with qi-deficiency constitution,and uric acid is negatively correlated with yin-deficiency constitution,in TCM conditioning treatment,attention should be paid to observe the changes in the corresponding indicators.