摘要
阿片类药物和中枢神经兴奋剂的成瘾性限制了相关药物的临床使用,近年来大量证据显示胶质细胞在阿片类药物和中枢神经兴奋剂的成瘾过程中起到了至关重要的作用,为研究其成瘾的细胞与分子机制找到了一种新思路,即非神经元通路。工作记忆损害、突触可塑性、神经免疫反应异常与药物成瘾是研究的热点。本文对胶质细胞表达的相关受体在成瘾过程中起到的作用及其机制做一综述,以期对阿片类药物和中枢神经兴奋剂成瘾的机制及治疗药物开发有更加深入的了解。
Opioids and central nervous system stimulants, which have addictive side effects, limit their use in clinical practice. Recently, accumulating evidence indicates that glial cells play a critical role in the addiction process of opioids and central nervous stimulants, which provides a new way to study the cellular and molecular mechanisms of drug addiction, namely non-neuronal pathway. Working memory impairment, synaptic plasticity, neuroimmune dysfunction in drug addiction are the hotspots in current research. Expecting for a better understanding of the mechanism of opioid and central nervous system stimulant addiction, as well as the development of novel drugs for treating drug addiction, this article reviews the role and mechanism of related receptors expressed by glial cells in the process of drug addiction.
作者
蒋峻宇
杨雨为
韩丽
刘靖鸿
李兵
郑华
穆敏
陶欣荣
JIANG Junyu;YANG Yuwei;HAN Li;LIU Jinghong;LI Bing;ZHENG Hua;MU Min;TAO Xinrong(Key Laboratory of Industrial Dust Purification and Occupational Health of the Ministry of Education,Anhui University of Science and Technology,Huainan,232001,,China;Key Laboratory of Industrial Dust Deep Reduction and Occupational Health and Safety of Anhui Higher Education Institutes,Anhui University of Science and Technology,Huainan,232001,China;School of Medicine,Anhui University of Science and Technology,Huainan,232001,China)
出处
《中国药物依赖性杂志》
CAS
CSCD
2021年第3期167-173,192,共8页
Chinese Journal of Drug Dependence
基金
国家自然科学基金项目(81471161)
大学生创新创业计划项目(201810361105)
大学生创客实验室建设计划(2016ckjh074)。