奥曲肽联合一贯煎合猪苓汤治疗肝肾阴虚型肝肾综合征临床研究

Clinical study on Octreotide combined with Yiguanjian and Zhuling decoction in treating liver and Kidney Yin deficiency type hepatorenal syndrome

目的分析肝肾阴虚型肝肾综合征采用奥曲肽联合一贯煎合猪苓汤治疗的临床效果。方法采用随机数字表法将2020年1月—2021年1月收治的82例肝肾阴虚型肝肾综合征患者分为对照组和观察组,对照组(n=41)使用奥曲肽治疗,观察组(n=41)使用奥曲肽联合一贯煎合猪苓汤治疗,对比2组治疗总有效率、症状消失时间、不良反应发生率。结果观察组治疗总有效率较对照组更高,且水肿消退时间、腹胀消失时间、腹腔积液消失时间更短,差异有统计学意义(P<0.05);2组恶心呕吐、皮疹、腹痛等不良反应总发生率差异无统计学意义(P>0.05)。结论肝肾阴虚型肝肾综合征采用奥曲肽联合一贯煎合猪苓汤治疗可有效改善症状,加速肢体水肿和腹胀消退,且安全可靠,值得推广。

Objective To analyze the clinical effect of octreotide combined with Yiguanjian and Zhuling Decoction for liver and kidney yin deficiency liver and renal syndrome.Methods Using random number table method,82 patients with liver and kidney yin deficiency hepatorenal syndrome patients admitted to our hospital from January 2020 to January 2021 were divided into control group and observation group.The control group(n=41)was used For octreotide treatment,the observation group(n=41)was treated with octreotide combined with Yiguanjian and Zhuling Decoction to compare the total effective rate of treatment,the time of symptom improvement,and the incidence of adverse reactions between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the time to disappear of edema,abdominal distension,and abdominal effusion was shorter.The difference in data was statistically significant(P<0.05);the two groups of nausea,vomiting,rash,There was no significant difference in the total incidence of adverse reactions such as abdominal pain(P>0.05).Conclusion The treatment of hepatorenal syndrome with liver and kidney yin deficiency combined with octreotide combined with Yiguanjian and Zhuling Decoction can improve symptoms,accelerate the resolution of limb edema and abdominal distension,and is safe and worthy of promotion.