血清sCD40L、MMP-9在子宫肌瘤术中的表达及与术后复发的相关性

The expression of serum sCD40L and MMP-9 in hysteromyoma surgery and its correlation with postoperative recurrence

目的;探讨血清sCD40L、MMP-9、CTGF、GSH-Px、T-AOC在行宫腔镜术子宫肌瘤患者中的表达及与术后复发的相关性。方法:按照宫腔镜术后疾病是否复发将医院收治的60例行宫腔镜术子宫肌瘤患者分组,对照组30例患者代表复发组,观察组30例患者代表未复发组。对比两组患者手术指标,术前及术后24 h的血清sCD40L、MMP-9、CTGF、GSH-Px、T-AOC水平变化,分析.上述指标与患者术后复发的关系。结果:观察组和对照组的手术指标无差异(P>0.05);观察组患者治疗后的血清MMP-9、CTGF和s CD40L水平优于对照组(P<0.05);观察组患者的氧化应激水平优于对照组(P<0.05);Lgistic多因素回归分析发现上述指标与患者术后复发具有密切的关系。结论:血清sCD40L、MMP-9、CTGF、GSH-Px、T-AOC在行宫腔镜术子宫肌瘤患者中存在异常表达的情况,且与术后复发具有相关性。

Objective:To investigate the expression of serum sCD40L,MMP-9,CTGF,GSH PX and T-AOC in patients with hysteromyoma after hysteroscopy and their correlation with postoperative recurrence.Methods:according to the recurrence of disease after hysteroscopy,60 patients with hysteromyoma underwent hysteroscopy in hospital were divided into control group(30 cases)and observation group(30 cases).The serum levels of sCD40L,MMP-9,CTGF,GSH PX and T-AOC before and 24 hours after operation were compared between the two groups,and the relationship between the above indexes and postoperative recurrence was analyzed.Results:there was no difference in the operation indexes between the observation group and the control group(P>0.05);The serum levels of MMP-9,CTGF and sCD40L in the observation group after treatment were better than those in the control group(P<0.05);The level of oxidative stress in the observation group was better than that in the control group(P<0.05);Logistic regression analysis showed that the above indexes were closely related to postoperative recurrence.Conclusion:the abnormal expression of serum sCD40L,MMP-9,CTGF,GSH PX and T-AOC in patients with hysteromyoma after hysteroscopy is correlated with the recurrence rate.