期刊文献+

粉尘螨滴剂舌下免疫治疗变应性鼻炎效果分析 被引量:1

下载PDF
导出
摘要 目的:观察粉尘螨滴剂(畅迪)舌下免疫治疗变应性鼻炎的临床疗效。方法:变应性鼻炎患者95例,予以标准化粉尘螨滴剂舌下免疫治疗,比较治疗前、治疗后12个月、24个月鼻部症状评分(NSS)和视觉模拟评分(VAS),记录治疗期间的不良反应。结果:治疗前患者喷嚏、流涕、鼻痒、鼻塞症状NSS评分分别为1.31±0.67分,1.83±0.96分,1.56±0.83分和1.72±0.77分;治疗后12个月分别降至0.31±0.05分,0.30±0.04分,0.22±0.04和0.38±0.05分,差异均有统计学意义(P<0.05);治疗后24个月进一步分别降至0.09±0.04分,0.05±0.02分,0.05±0.02分和0.09±0.03分,与治疗后12个月比较,差异均有统计学意义(P<0.05)。治疗前VAS评分为6.25±1.49分,治疗后12个月为1.54±1.17分,较治疗前明显下降,差异有统计学意义(P<0.05),治疗后24个月VAS评分进一步下降至0.26±0.05分,与治疗后12个月的差异有统计学意义(P<0.05)。12例患者出现轻度不良反应,均未停止免疫治疗。结论:舌下免疫治疗是治疗变应性鼻炎的有效方法,治疗12个月鼻部症状明显改善,治疗持续24个月鼻部症状进一步改善。
出处 《交通医学》 2021年第4期386-388,共3页 Medical Journal of Communications
  • 相关文献

参考文献7

二级参考文献62

  • 1Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update ( in collaboration with the World Heahh Organization, GA2LEN and AllerGen ) [ J ]. Allergy, 2008, 63 Suppl 86: 8-160.
  • 2Burks AW, Calderon MA, Casale T, et al. Update on allergy immunotherapy : American Academy of Allergy, Asthma & Immunology/ European Academy of Allergy and Clinical Immunology/PRACTALL consensus report [ J ]. J Allergy Clin Immunol, 2013, 131(5): 1288-1296.
  • 3Canonica GW, Cox L, Pawankar R, et al. Sublingual immunotherapy: World Allergy Organization position paper 2013 update[J]. World Allergy Organ J, 2014, 7(1) :6.
  • 4Li J, Sun B, Huang Y, et ak A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in china[J]. Aller. 2009. 64(7): 1083-1092.
  • 5Aydogan M, Eifan AO, Keles S, et al. Sublingual immunotherapy in children with allergic rhinoconjunctivitis mono-sensitized to house-dust-mites: a double-blind-placebo-controlled randomised trial[J]. Respir Med, 2013, 107(9) : 1322-1329.
  • 6Bousquet PJ, Combescure C, Neukirch F, et al. Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines [ J]. Allergy, 2007, 62 (4) : 367-372.
  • 7Simoens S. The cost-effectiveness of immunotherapy for respiratory allergy: a review[J]. Allergy , 2012, 67(9) : 1087-1105.
  • 8Moingeon P. Update on immune mechanisms associated with sublingual immunotherapy: Practical implications for the clinician [J]. J Allergy Clin Immunol Pract,2013, 1(3) : 228-241.
  • 9Wang DH, Chen L, Cheng L, et al. Fast onset of action of sublingual immunotherapy in house dust mite-induced allergic rhinitis : a multicenter, randomized, double-blind, placebo- controlled trial[J]. Laryngoscope, 2013, 123(6) : 1334-1340.
  • 10Shao J, Cui YX, Zheng YF, et al. Efficacy and safety of sublingual immunotherapy in children aged 3-13 years with allergic rhinitis[J]. Am J Rhinol Allergy, 2014, 28(2) : 131-139.

共引文献178

同被引文献15

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部