典型SSRIs类抗抑郁药对鱼类的毒性效应研究进展

Research Progress on Toxic Effects of Typical SSRIs Antidepressants on Fish

选择性血清素再摄取抑制剂(selective serotonin reuptake inhibitors,SSRIs)是一类在临床上具有良好治疗效果的抗抑郁药物,由于使用量巨大,在水环境中频繁被检出,其潜在生态毒性效应引起人们的广泛关注。鱼类作为水生脊椎动物,具有和人类相似的神经调控系统,更易受到水体中残留的SSRIs的影响。本文综述了SSRIs在鱼类体内的代谢和生物积累效应,以及SSRIs对鱼类产生的生长发育毒性、生殖毒性和神经行为毒性,并对未来该领域的研究进行了展望。

Selective serotonin reuptake inhibitors(SSRIs)are a class of antidepressants which are used widely in human clinical medicine.Due to high prescription rates and ubiquitous use,SSRIs are frequently detected in the aquatic environment,and their potential ecotoxic effects have caused widespread global concern.As vertebrates,fish show some homology in neuroregulatory system compared to humans,and thus,can be susceptible to effects due to psychotropic drug contaminants in the water.This review outlines the metabolism and bioaccumulation of SSRIs in fish and introduces the influence of SSRIs on the growth and development,reproduction,and behavior of fish.Based on published data,we point out the limitations of current toxicological research on SSRIs and propose future studies for this important class of chemicals in aquatic toxicology.