摘要
选择性血清素再摄取抑制剂(selective serotonin reuptake inhibitors,SSRIs)是一类在临床上具有良好治疗效果的抗抑郁药物,由于使用量巨大,在水环境中频繁被检出,其潜在生态毒性效应引起人们的广泛关注。鱼类作为水生脊椎动物,具有和人类相似的神经调控系统,更易受到水体中残留的SSRIs的影响。本文综述了SSRIs在鱼类体内的代谢和生物积累效应,以及SSRIs对鱼类产生的生长发育毒性、生殖毒性和神经行为毒性,并对未来该领域的研究进行了展望。
Selective serotonin reuptake inhibitors(SSRIs)are a class of antidepressants which are used widely in human clinical medicine.Due to high prescription rates and ubiquitous use,SSRIs are frequently detected in the aquatic environment,and their potential ecotoxic effects have caused widespread global concern.As vertebrates,fish show some homology in neuroregulatory system compared to humans,and thus,can be susceptible to effects due to psychotropic drug contaminants in the water.This review outlines the metabolism and bioaccumulation of SSRIs in fish and introduces the influence of SSRIs on the growth and development,reproduction,and behavior of fish.Based on published data,we point out the limitations of current toxicological research on SSRIs and propose future studies for this important class of chemicals in aquatic toxicology.
作者
杨慧婷
李霞
陈辉辉
毛志刚
谷孝鸿
梁雪芳
Yang Huiting;Li Xia;Chen Huihui;Mao Zhigang;Gu Xiaohong;Liang Xuefang(Inner Mongolia Key Laboratory of Environmental Pollution Control&Waste Resource Reuse,School of Ecology and Environment,Inner Mongolia University,Hohhot 010021,China;State Key Laboratory of Lake Science and Environment,Nanjing Institute of Geography and Limnology,Chinese Academy of Sciences,Nanjing 210008,China)
出处
《生态毒理学报》
CAS
CSCD
北大核心
2021年第3期28-39,共12页
Asian Journal of Ecotoxicology
基金
国家自然科学基金资助项目(21866024,41907222)
内蒙古大学校级大学生创新创业训练计划项目(202017400)
中国科学院饮用水科学与技术重点实验室专项经费(20K05KLDWST)。
关键词
选择性血清素再摄取抑制剂
鱼类
生长发育毒性
生殖毒性
神经行为毒性
selective serotonin reuptake inhibitors
fish
growth and development toxicity
reproductive toxicity
neurobehavioral toxicity