rhEGF联合羟糖苷滴眼液治疗空中乘务员干眼的临床疗效分析

Analysis of clinical curative effect of rhEGF combined with hydroxycarboside eye drops on dry eye in flight attendants

目的观察重组人表皮生长因子(rhEGF)联合羟糖苷滴眼液治疗空中乘务员干眼(DE)的临床疗效。方法选取2017年4月—2018年10月在民航西安医院诊断为干眼的58例(116眼)女性空中乘务员患者作为观察对象,采用随机数字表法随机平均分为两组:对照组与观察组,每组58只眼。对照组仅给予羟糖苷滴眼液治疗,观察组给予rhEGF联合羟糖苷滴眼液治疗,比较两组干眼患者治疗前后主观症状改善情况、泪膜破裂时间(BUT)、角膜荧光素染色(CFS)评分、基础泪液分泌试验(SIT)以及不良反应。结果治疗4周后,观察组总有效率(93.10%)显著高于对照组(77.59%),在主观症状、BUT、SIT等方面的改善情况也均显著优于对照组(均P<0.05)。结论 rhEGF联合羟糖苷滴眼液治疗空中乘务员干眼安全,有效率高,值得临床推广应用。

Objective To observe the clinical effect of recombinant human epidermal growth factor(rhEGF) combined with hydroxycarboside eye drops on dry eye(DE) in flight attendants. Methods A total of 58 female flight attendants(116 eyes),who were diagnosed with DE in Civil Aviation Xi’an Hospital from April 2017 to October 2018,were selected as observation objects,and randomly divided equally into two groups by the random number table method :a control group and a research group,58 eyes in each group. The patients in the control group single received hydroxycarboside eye drops,and those in the research group received rh EGF combined with hydroxycarboside eye drops. The improvement of the clinical subjective symptoms,tear break-up time(BUT),corneal fluorescence staining(CFS) scores and SchirmerⅠ test(SIT) in two groups were compared before and after treatment. Results After four weeks treatment,the total effective rate in the research group(93.10%) was significantly higher than that in the control group(77.59%). The improvement of subjective symptoms,BUT and SⅠT in research group were also significantly better than those in the control group(all P<0.05). Conclusion The rhEGF combined with hydroxycarboside eye drops is effective and safe in the treatment of dry eye in flight attendants,which is worthy of clinical application.