铁死亡在阿尔茨海默病中的研究进展

Research Progress of Ferroptosis in Alzheimer’s Disease

铁死亡是新近发现的一种以铁依赖性脂质过氧化和活性氧诱导的程序性细胞死亡。阿尔茨海默病是一种因神经细胞变性而导致的神经退行性疾病。最近研究显示铁死亡与阿尔茨海默病关系密切,但其具体机制尚不明确,可能通过铁代谢、氨基酸代谢和脂质代谢等途径影响体内铁离子的积累,进而诱导神经细胞发生铁死亡。文章围绕铁死亡的特点及其调控机制、铁死亡与阿尔茨海默病的关系以及近年靶向铁死亡对阿尔茨海默病进行治疗的研究进展进行综述,以期为临床阿尔茨海默病的防治提供参考。

Ferroptosis is a programmed cell death induced by iron-dependent lipid peroxidation and reactive oxygen species.Alzheimer’s disease(AD)is a neurodegenerative disease caused by the degeneration of nerve cells.Recent studies have revealed a close relationship between ferroptosis and AD.However,the exact mechanism remains unclear.AD may affect the accumulation of iron ions through iron,amino acid and lipid metabolism,and then induce ferroptosis in nerve cells.In order to provide reference for clinical prevention and therapy of AD,this paper reviews the characteristics and regulatory mechanism of ferroptosis,relationship between ferroptosis and AD,and treatment of AD targeting ferroptosis.