摘要
The estrogen receptor(ER)-negative breast cancer subtype is aggressive with few treatment options available.To identify specific prognostic factors for ER-negative breast cancer,this study included 705,729 and 1034 breast invasive cancer patients from the Surveillance,Epidemiology,and End Results(SEER)and The Cancer Genome Atlas(TCGA)databases,respectively.To identify key differential kinase-substrate node and edge biomarkers between ER-negative and ERpositive breast cancer patients,we adopted a network-based method using correlation coefficients between molecular pairs in the kinase regulatory network.Integrated analysis of the clinical and molecular data revealed the significant prognostic power of kinase-substrate node and edge features for both subtypes of breast cancer.Two promising kinase-substrate edge features,CSNK1A1-NFATC3 and SRC-OCLN,were identified for more accurate prognostic prediction in ERnegative breast cancer patients.
基金
supported by the National Key R&D Program of China(Grant No.2017YFA0505500)
the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA12010000)
the National Program on Key Basic Research Project of China(Grant Nos.2014CBA02000 and 2014CB910500)
the National Natural Science Foundation of China(Grant Nos.91029301,30700397,91529303,and 31771476)
the support of the SANOFI-SIBS Distinguish Young Scientist Award Scholarship Program。
