摘要
Six new bisabolane-type phenolic sesquiterpenoids,including plakordiols A-D(1-4),(7 R,10 R)-hydroxycurcudiol(5)and(7 R,10 S)-hydroxycurcudiol(6)were isolated from the marine sponge Plakortis simplex collected from the South China Sea.Their structures were determined based on extensive analysis of spectroscopic data.Their configurations were assigned by coupling constant analysis,NOESY correlations,and the modified Mosher’s method.Furthermore,their cytotoxic and antibacterial activities were evaluated.
基金
supported by the Fundamental Research Funds for Zhejiang Provincial Universities and Research Institutes(No.2019J00012)
the National Natural Science Foundation of China(Nos.U1605221,41906075,81803426,and41576130)
the New Shoot Talents Program of Zhejiang Province(No.2019R411020)
the Innovative Research Team of Highlevel Local Universities in Shanghai。
