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基于“脾-陈气-脉积”探讨糖尿病早期动脉粥样硬化病因病机 被引量:9

Discussion on Etiology and Pathogenesis of Early Atherosclerosis in Diabetes Mellitus Based on"Spleen,Chen Qi and Mai Ji"
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摘要 大血管病变是糖尿病主要致死原因之一,动脉粥样硬化是其病理基础。中医药治疗糖尿病动脉粥样硬化疗效显著,但缺乏深入系统的病机阐述。根据“癥瘕积聚”理论,本课题组前期提出了“脉积”学说,本文着眼病变早期,认为脾不散精是始动环节,陈气是病理产物和致病因素,陈气聚而不散,损伤血脉形成脉积。治疗上强调早期干预是延缓或逆转病情进展的关键,健脾除陈为基本治则,痰瘀同治应贯穿全程。本文基于“脾-陈气-脉积”病机观,阐释糖尿病早期动脉粥样硬化的中医理论内涵和现代医学外延,为本病的中医药防治提供新思路。 The macrovascular complication is one of the main causes of death in diabetes mellitus,and atherosclerosis is its pathological basis.Traditional Chinese medicine(TCM)has a certain therapeutic effect on diabetic atherosclerosis,but lacking in-depth and systematic pathogenesis."Mai Ji"theory was proposed according to the theory of"Zhengjia-Jiju"early.This paper introduces the dysfunction of the spleen transforming essence is the initial step and Chen Qi is the pathological product and pathogenic factor in the early stage of this disease.Chen Qi’s aggregation and dispersion imbalance damage blood vessels,resulting in the formation of Mai Ji.It is proposed that early intervention is a key measure to delay or reverse disease progression.Regarding the treatment method,it is suggested that strengthening the spleen and eliminating Chen Qi is the basic treatment,and resolving the phlegm and blood stasis should throughout the whole process.Based on the pathogenesis of"Spleen,Chen Qi and Mai Ji",the theoretical connotation of TCM and the modernmedicineextension of early atherosclerosis indiabetic are explained to provide new ideas for the prevention and treatment of TCM.
作者 远佳瑶 符宇 冯志海 李蕾蕾 YUAN Jia-yao;FU Yu;FENG Zhi-hai;LI Lei-lei(Henan University of Chinese Medicine,Zhengzhou 450000,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处 《中国中医基础医学杂志》 CAS CSCD 北大核心 2021年第8期1210-1212,1265,共4页 JOURNAL OF BASIC CHINESE MEDICINE
基金 国家自然科学基金青年基金项目(81704011)-鳖甲煎丸调控NLRP3炎症小体对糖尿病大血管病变内皮损伤保护作用的机制研究 河南省重点研发与推广专项(192102310157)-基于真实世界中医临床数据T2DM-CHD循证证据构建研究 河南省卫生健康委员会国家中医临床研究基地科研专项(2019JDZX026)-基于NLRP3炎症体-细胞焦亡途径探讨鳖甲煎丸保护糖尿病大血管病变内皮损伤的分子机制及物质基础 河南省中医药科学研究专项(2018Y2061)-基于真实世界中医干预糖尿病患者PCI术后循证证据构建与示范研究。
关键词 糖尿病 动脉粥样硬化 脉积 陈气 脾不散精 Diabetes mellitus Atherosclerosis Mai Ji Chen Qi Dysfunction of spleen transforming essence
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