妇产科围手术期术后生殖道感染抗菌药物的预防效果

Effect of antibacterial drugs on prevention of postoperative genital tract infection in patients of obstetrics and gynecology department

目的研究妇产科围手术期术后生殖道感染抗菌药物的预防效果。方法选取2017年1月-2017年12月北京垂杨柳医院收治的180例妇产科手术患者为研究对象,按随机数字表法分成研究组和对照组,均为90例。对照组仅在手术前30 min静脉滴注头孢西丁2 g进行抗感染治疗;研究组患者在手术前进行相同操作,手术后重复运用1次抗菌药物。比较两组术后并发症发生率、有效率、白细胞及中性粒细胞计数、两组血液流变学参数。结果研究组术后并发症发生率低于对照组(P<0.05)。研究组患者有效率为96.67%,对照组为82.22%,差异有统计学意义(P<0.05)。两组患者治疗前白细胞、中性粒细胞、淋巴细胞均高于正常值。治疗后,两组上述指标均下降(P<0.05),尤其研究组降低最显著(P<0.05)。治疗前,两组患者纤维蛋白原含量、血小板聚集率、全血黏度、血浆黏度水平比较,无统计学差异。治疗后,对照组上述指标均上升(P<0.05),研究组无显著变化,研究组患者纤维蛋白原含量、血小板聚集率、全血黏度、血浆黏度水平测得值均低于对照组(P<0.05)。结论合理使用抗菌药物可以对妇产科围手术期术后生殖道感染起到预防作用。

OBJECTIVE To observe the effect of antibacterial drugs on prevention of postoperative genital tract infection in patients of obstetrics and gynecology department.METHODS A total of 180 patients who received surgeries in department of obstetrics and gynecology of Beijing Chuiyangliu Hospital from Jan 2017 to Dec 2017 were recruited as the study subjects and randomly divided into the study group and the control group,with 90 cases in each group.The control group was only given intravenous drip of 2 g cefoxitin 30 min before the surgery,while the study group was treated with the same procedure before the surgery and given antibiotic therapy one more time after the surgery.The incidence of postoperative complications,effective rate,white blood cell and neutrophils counts,and hemorheologic parameters were observed and compared between the two groups of patients.RESULTS The incidence of postoperative complications of the study group was significantly lower than that of the control group(P<0.05).The effective rate was 96.67%in the study group,82.22%in the control group,and there was significant difference(P<0.05).The white blood cell counts,neutrophils counts and lymphocytes counts of the two groups of patients were significantly higher than the normal values before the treatment,while the above indexes of the two groups declined after the treatment(P<0.05),the indexes of the study group were reduced significantly(P<0.05).There were no significant differences in the fibrinogen content,platelet aggregation rate,whole blood viscosity and plasma viscosity between the two groups of patients before the treatment;the above indexes of the control group were elevated significantly after the treatment(P<0.05),there were no significant changes in the study group;the fibrinogen content,platelet aggregation rate,whole blood viscosity and plasma viscosity of the study group were significantly lower than those of the control group(P<0.05).CONCLUSION The reasonable use of antibiotics may prevent the postoperative genital tract infection in the patients of obstetrics and gynecology department.