胎膜早破孕产妇结合珠蛋白基因多态性与生殖道感染类型

Gene polymorphisms of haptoglobin and types of genital tract infections in patients with premature rupture of membranes

目的分析胎膜早破(PROM)孕产妇结合珠蛋白(Hp)基因多态性及生殖道感染类型。方法选择2017年1月-2020年1月河南理工大学第一附属医院96例PROM患者为病例组,另选择同期于医院待产的48名正常孕妇为对照组,两组均进行Hp基因多态性和生殖道感染检测,比较两组Hp基因多态性和生殖道感染类型,并分析Hp基因多态性及生殖道感染类型与PROM的相关性。结果病例组Hp2-2基因型频率高于对照组(P<0.05),Hp1-1基因型频率、Hp2-1基因型频率与对照组比较,无统计学差异;病例组Hp2基因频率高于对照组(P<0.05),Hp1基因频率与对照组比较,无统计学差异;病例组解脲支原体(UU)、沙眼衣原体(CT)、细菌性阴道病(BV)、白假丝酵母、混合感染比例均高于对照组(P<0.05),滴虫感染比例与对照组比较,无统计学差异。结论Hp基因多态性与PROM具有相关性,等位基因Hp2可能对PROM发生起到促进作用,且生殖道感染类型与PROM有关,生殖道UU、CT、BV、白假丝酵母、混合感染的女性更容易发生PROM,对此类孕妇需予以重视。

OBJECTIVE To analyze the gene polymorphisms of haptoglobin(Hp)and types of genital tract infection in the patients with premature rupture of membranes(PROM).METHODS A total of 96 PROM patients who were treated in the First Affiliated Hospital of Henan Polytechnic University from Jan 2017 to Jan 2020 were assigned as the case group,meanwhile,48 normal pregnant women awaiting delivery were set as the control group.The gene polymorphisms of Hp and types of genital tract infections were detected and compared between the two groups,and the correlation between the gene polymorphisms of Hp,types of genital tract infections and the PROM was observed.RESULTS The frequency of Hp2-2 genotype of the case group was significantly higher than that of the control group(P<0.05);there were no significant differences in the frequencies of Hp1-1 and Hp2-1 between the case group and the control group;the frequency of Hp2 of the case group was significantly higher than that of the control group(P<0.05),and there was no significant difference in the frequency of Hp1 gene between the case group and the control group.The proportions of the patients with Ureaplasma urealyticum(UU),Chlamydia trachomatis(CT),bacterial vaginosis(BV),Candida albicans and mixed infections were significantly higher in the case group than in the control group(P<0.05);there was no significant difference in the proportion of the patients with trichomonas infection between the case group and the control group.CONCLUSION The Hp gene polymorphisms are associated with PROM,allele Hp2 may promote the occurrence of PROM,and the type of genital tract infection is associated with PROM.The female who have genital tract UU,CT,BV,C.albicans and mixed infections are more likely to have PROM,to whom the high attention should be paid.