MRI指导下超时间窗动脉取栓对轻中度前循环急性脑梗死患者认知功能及血清hs-CRP的影响

Effects of MRI-Guided Exceed Time W indow Arterial Embolectomy on Cognitive Function and Serum hs-CRP in Patients with Mild to Moderate Anterior Circulation Acute Cerebral Infarction

目的分析MRI指导下超时间窗动脉取栓对轻中度前循环急性脑梗死患者认知功能及血清超敏C反应蛋白(hs-CRP)的影响。方法选取我院2019年1月至2019年12期间收治的94例轻中度前循环急性脑梗死患者为研究对象,根据治疗方法分为常规治疗组(n=45)和动脉取栓组(n=49),比较两组患者的治疗有效率,治疗前和治疗后不同时间点美国国立卫生研究院卒中量表(NIHSS)评分、简易精神状态量表(MMSE)、蒙特利尔认知评估量表(MoCA)、血清hs-CRP水平,并比较治疗过程中的不良反应。结果动脉取栓组患者的治疗有效率87.76%,高于常规治疗组(71.11%,χ^(2)=4.029,P=0.045);与治疗前相比,两组患者治疗后NIHSS评分明显降低,MMSE、MoCA评分明显升高,且同时间点下动脉取栓组上述评分变化更显著(P<0.05);与治疗前相比,两组患者治疗后血清中hs-CRP水平明显降低,同时间点下动脉取栓组的hs-CRP降低更显著(P<0.05);两组患者的不良反应发生率无统计学差异(P>0.05)。结论在MRI指导下对超时间窗的轻中度前循环急性脑梗死患者进行动脉取栓能够有效改善患者的神经、认知功能缺损以及炎症反应,治疗安全性较高。

Objective To analyze effects of MrI-guided exceed time window arterial embolectomy on cognitive function and serum high-sensitivity C-reactive protein(hs-CrP)in patients with mild to moderate anterior circulation acute cerebral infarction(ACI).Methods A total of 94 patients with mild to moderate anterior circulation ACI admitted to the hospital from January 2019 to December 2019 were enrolled as study objects.Different treatment methods were divided into a routine treatment group(n=45)and a arterial embolectomy group(n=49).The response rate of treatment,scores of National Institutes of Health Stroke Scale(NIHSS),Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA),level of serum hs-CrP before and after treatment,and adverse reactions during treatment were compared between the two groups.results The response rate of treatment in the arterial embolectomy group was higher than that in the routine treatment group(87.76%vs.71.11%)(χ^(2)=4.029,P=0.045).After treatment,NIHSS scores were significantly decreased,while scores of MMSE and MoCA were significantly increased in both groups.The changes in the above scores were more significant in the arterial embolectomy group(P<0.05).After treatment,levels of serum hs-CrP in both groups were significantly decreased.The decrease of hs-CrP in the arterial embolectomy group was more significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of MrI-guided exceed time window arterial embolectomy for patients with mild to moderate anterior circulation ACI can effectively improve neurological and cognitive function impairment and inflammatory response,with high treatment safety.