PET/CT对肺癌淋巴结转移的诊断效能研究

Diagnostic Efficiency of PET/CT for Lymph Node Metastasis of Lung Cancer

目的探讨正电子发射计算机断层显像/计算机体层成像(PET/CT)对肺癌淋巴结转移的诊断效能。方法选取2017年1月至2018年12月我院收治的肺癌患者89例为研究对象,对患者进行常规CT检查及PET/CT检查,分析淋巴结转移的诊断情况,以病理结果为“金标准”,探讨PET/CT对肺癌淋巴结转移的诊断效能。结果病理测量、CT检查及PET/CT检查结果分别为(3.97±1.58)、(4.15±1.27)、(4.32±1.61)mm,三者比较无统计学差异(P>0.05);临床病理分期N_(0)、N_(1)、N_(2)、N_(3)分别有30、26、33、0例;PET/CT检查结果发现N_(0)、N_(1)、N_(2)、N_(3)分别有27、22、30、0例,准确率分别为90.00%、84.62%、90.91%;CT检查结果发现N_(0)、N_(1)、N_(2)、N_(3)分别有26、13、24、0例,准确率分别为86.67%、50.00%、72.73%。89例患者在手术后清扫出390组淋巴结,以术后病理结果为标准,PET/CT检查对肺癌淋巴结转移的诊断敏感度、特异性、准确度、阳性预测值、阴性预测值均显著高于CT检查。结论PET/CT检查、CT检查在肺癌淋巴结转移中均具有一定的诊断价值,且PET/CT检查的诊断效能显著高于CT检查,但仍存在一定的假阳性及假阴性,在临床诊断中需结合患者的临床资料提高诊断准确率。

Objective Toexplore diagnostic efficiency of positron emission tomography/computed tomography(PET/CT)for lymph node metastasis of lung cancer.Methods 89 patients with lung cancer who were admitted to the hospital from January 2017 to December 2018 were enrolled.The patients underwent routine CT examination and PET/CT examination.The diagnosis conditions for lymph node metastasis were analyzed.Taking pathological results as the golden standard,the diagnostic efficiency of PET/CT for lymph node metastasis of lung cancer was explored.Results The results of pathological measurement,CT examination,and PET/CT examination were(3.97±1.58)mm,(4.15±1.27)mm,and(4.32±1.61)mm,respectively.There was no significant difference among the three(P>0.05).There were 30 cases,26 cases,33 cases,and 0 case with clinical pathological staging at stage N_(0),N_(1),N_(2),and N_(3).The PET/CT examination results found that there were 27 cases,22 cases,30 cases,and 0 case at stage N_(0),N_(1),N_(2),and N_(3),respectively.The accuracy rates were 90.00%,84.62%,and 90.91%,respectively.The results of CT examination found that there were 26 cases,13 cases,24 cases,and 0 case at stage N_(0),N_(1),N_(2),and N_(3),respectively.The accuracy rates were 86.67%,50.00%,and 72.73%,respectively.Among the 89 patients,there were 390 lymph nodes cleared out after surgery.Taking postoperative pathological results as standard.The diagnostic sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of PET/CT examination for lymph node metastasis of lung cancer were significantly higher than those of CT examination.Conclusion Both PET/CT and CT examinations are of certain diagnostic value in lymph node metastasis of lung cancer.The diagnostic efficiency of PET/CT examination is significantly higher than that of CT examination.However,there are still some false positives and false negatives.In clinical diagnosis,patients’clinical data should be combined to improve diagnostic accuracy.