铁死亡在急性肾损伤中的作用机制

Mechanism of ferroptosis in acute kidney injury

急性肾损伤(AKI)起病急骤,目前缺少动态监测肾脏损伤演变的早期、敏感指标。在各类AKI模型中均有铁死亡过程,参与铁死亡的特定蛋白、基因将有望成为AKI发生发展的预测因子。铁死亡的发生与铁、氨基酸、脂质代谢密切相关,通过炎症反应、内质网应激和自噬等病理过程参与AKI的发展。研究证实多种靶向作用于铁死亡的药物对AKI的治疗具有良好的前景。本文就铁死亡参与AKI发展的作用机制及干预铁死亡的药物研究进展进行综述。

Acute kidney injury(AKI)has a rapid onset,but there is no early and sensitive indicator for dynamic monitoring of kidney function.Studies have found ferroptosis occured in various AKI models,and specific proteins and genes involved in ferroptosis are expected to be predictors of the occurrence and development of AKI.Ferroptosis is closely related to the metabolism of iron,amino acids and lipids,and it participates in development of AKI through pathological processes such as inflammation,endoplasmic reticulum stress and autophagy.Studies have confirmed that many kinds of drugs targeting on ferroptosis have achieved good efficacy in the treatment of AKI.This article reviews the mechanism of ferroptosis involved in development of AKI and the latest research progress of drugs for treatment of ferroptosis.