老年2型糖尿病患者合并肌少症的情况及影响因素分析

Incidence and influencing factors of concormitant sarcopenia in elderly patients with type 2 diabetes mellitus

目的了解老年2型糖尿病(T2DM)患者合并肌少症的情况,并分析其影响因素。方法选取287例老年T2DM患者,比较不同性别患者合并肌少症的发生率,及其合并肌少症与不合并肌少症者肌肉力量、身体成分、临床资料和体力活动水平。采用多因素Logistic回归分析影响不同性别老年T2DM患者并发肌少症的因素。结果老年T2DM患者合并肌少症的发生率为21.25%,男性、女性分别为18.05%、24.03%。男性合并肌少症的老年T2DM患者年龄、空腹血糖高于不合并肌少症者,糖尿病病程长于不合并肌少症者,体质指数、腰围、骨矿含量低于不合并肌少症者(P<0.05);女性合并肌少症的老年T2DM患者年龄、糖化血红蛋白、糖尿病病程高于或长于不合并肌少症者(P<0.05),体质指数、骨矿含量、25-羟基维生素D低于不合并肌少症者(P<0.05)。多因素分析结果显示,年龄、体质指数、糖尿病病程、骨矿含量是老年男性T2DM患者合并肌少症的影响因素;糖尿病病程、体质指数、骨矿含量是老年女性T2DM患者合并肌少症的影响因素(P<0.05)。结论老年T2DM患者合并肌少症的发生率较高。高龄、低体质指数、糖尿病病程长、低骨矿含量是老年男性T2DM患者合并肌少症的危险因素,糖尿病病程长、低体质指数、低骨矿含量是老年女性T2DM患者合并肌少症的危险因素。

Objective To explore the incidence of concomitant sarcopenia in elderly patients with type 2 diabetes mellitus(T2DM),and to analyze its influencing factors.Methods A total of 287 elderly T2DM patients were enrolled.The incidence rate of concomitant sarcopenia was compared between male and female patients,and muscle strength,body composition,clinical data,and physical activities levels were compared between individuals with and without concomitant sarcopenia.A multivariate Logistic regression analysis was performed on the influencing factors of developing concomitant sarcopenia in eldely male and female T2DM patients.Results The incidence rate of concomitant sarcopenia was 21.25%in elderly T2DM patients,18.05%in men and 24.03%in women.Elderly male T2DM patients complicated with sarcopenia were older,exhibited higheRFBG,longeRduration of diabetes,and loweRbody mass index(BMI),waist circumference and bone mineral content(BMC)than those without concomitant sarcopenia(P<0.05);elderly female T2DM patients complicated with sarcopenia were older,exhibited higheRhemoglobin A1c,longeRduration of diabetes,loweRBMI,BMC and 25-hydroxyvitamin D than those without concomitant sarcopenia(P<0.05).The results of multivariate analysis showed that age,BMI,duration of diabetes,and BMC were the influencing factors of developing concomitant sarcopenia in elderly male T2DM patients;duration of diabetes,BMI,and BMC were the influencing factors of developing concomitant sarcopenia in elderly female T2DM patients(P<0.05).Conclusion Elderly T2DM patients experience a relatively high incidence rate of concomitant sarcopenia.Advanced age,low BMI,longeRduration of diabetes,and low BMC are the risk factors foRdeveloping concomitant sarcopenia in elderly male T2DM patients.Prolonged duration of diabetes,low BMI,and low BMC are the risk factors foRdeveloping concomitant sarcopenia in elderly female T2DM patients.