共生菌群与眼部疾病关系的研究进展

Research progress in relationship of commensal microbes and ocular diseases

共生菌群是由细菌、病毒和真菌等微生物组成,与人体共同构成一套微生物-宿主共生系统,广泛存在于身体的各个部位,是人们一直以来研究的热点。以前普遍认为眼球表面并不存在任何微生物,直到眼表乳腺炎棒状杆菌的发现,研究者们开始密切关注共生微生物与眼部的关系。虽然发现的微生物群可以存在于眼表,但其发挥的免疫功能和作用途径仍需要深入探究,以便更全面地从微生物的角度揭开眼部疾病不为人知的一面。本文将简要概述目前所知的部分眼部微生物群,以及这些微生物群如何在眼表免疫中发挥作用。同时,也会介绍其他部位的微生物群对于眼部疾病的影响。

Commensal microbes are composed of microorganisms like bacteria,viruses,and fungi.It forms a microbe-host symbiosis system with the human body,which is widely existed in the host and has been a hot research topic for many years.It used to be generally believed that there were no microorganisms on the surface of the eyeball.Until the discovery of the Corynebacterium mastitides on the ocular surface,the relationship between commensal microbes and the eye has been gradually concerned.Although the discovered microbiota can exist on the ocular surface,the immune function and the underlying mechanism need to be explored to reveal the unknown side of ocular diseases from the perspective of microbes.This article aims to briefly overview the local eye microbiota and the role of microbiota in ocular surface immunity.Meanwhile,the impact of other microbiota on eye diseases will also be introduced.