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创伤敷料的分类及其治疗糖尿病足的研究进展 被引量:3

Classification of Wound Dressings and Their Research Progress in Treatment of Diabetic Foot Ulcer
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摘要 糖尿病足(diabetic foot ulcer,DFU)是糖尿病常见的并发症之一,也是导致足部溃疡以及截肢的重要原因。糖尿病伤口愈合不良的潜在机制尚不完全清楚。溃疡治疗的主要原则是伤口清创、敷料应用、血运重建、血糖调控和感染管理等,而创伤敷料在DFU治疗中发挥重要作用。临床敷料包括天然和合成的聚合物,这些材料可被加工成薄膜、泡沫、水胶体和水凝胶等形态。判断DFU溃疡创面发展阶段以及合理选择创伤敷料是其治疗的关键,但目前还没有一种创伤敷料能使DFU创面达到理想的愈合状态。因此,应从细胞、分子和基因水平等方面对DFU发病机制进行综合研究,加强多种功能创面敷料的研发,尤其是可维持细胞活力、具有增殖和分化功能的生物材料的联合疗法值得期待。 Diabetic foot ulcer(DFU),one of the most common complications of diabetes,is an important cause of foot ulcer and amputation.The underlying mechanisms of poor wound healing in diabetes are not fully understood.The main principles of DFU treatment include wound debridement,dressing application,revascularization,blood glucose control and infection management.Wound dressings play an important role in the treatment of DFU.Clinical dressings include natural and synthetic polymers,which can be processed into thin films,foams,hydrocolloids and hydrogels.It is important to judge the development stage of DFU and to reasonably choose wound dressings.However,no wound dressings can achieve ideal healing state of DFU wound at present.Therefore,it is necessary to study the pathogenesis of DFU at the cellular,molecular and genetic levels,and to develop wound dressings with multiple functions.Especially,the combined therapy with advanced biomaterials that can maintain cell viability,proliferation and differentiation is the future research direction.
作者 吴知仁 曾子都 熊含春 陈雄林 WU Zhi-rena;ZENG Zi-doua;XIONG Han-chun;CHEN Xiong-linb(Jiujiang University,Jiujiang 332000,China;Department of Medical Genetics and Histoembryology of School of Basic Medical Sciences,Jiujiang University,Jiujiang 332000,China;Department of Anesthesiology,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)
出处 《实用临床医学(江西)》 CAS 2021年第4期93-98,共6页 Practical Clinical Medicine
基金 国家自然科学基金项目(81960159) 江西省自然科学基金项目(20202BAB206022) 江西省教育厅科技研究项目(GJJ190004) 江西省卫生健康委员会科技计划项目(201930009)。
关键词 糖尿病足 创伤敷料 分类 发病机制 治疗 diabetic foot ulcer wound dressings classification pathogenesis treatment
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