克罗恩病非药物治疗的研究进展

Advances in non-drug therapy for Crohn’s disease

克罗恩病(Crohn’s disease,CD)是一种胃肠道的慢性非特异性炎性肉芽肿性疾病,其病因尚不明确。病变可累及自口腔至肛门各段消化道,病情容易反复发作,严重影响患者的生活质量。目前临床上用来治疗CD的药物主要是氨基水杨酸制剂、糖皮质激素、免疫抑制剂和生物制剂,药物治疗可有效诱导缓解,改善临床症状,但缺乏持久性。近年来,非药物方法治疗CD的应用率逐渐提高,包括肠内营养(enteral nutritions,EN)、粪菌移植(fecal microbiota transplantation,FMT)、间充质干细胞移植(mesenchymal stem cell transplantations,MSCs)和粒细胞单核细胞吸附分离(granulocyte and monocyte apheresis,GMA)。本文主要对这4种非药物治疗CD的研究进展作一概述。

Crohn’s disease(CD)is a chronic,non-specific,inflammatory granulomatous disease of the gastrointestinal tract,whose etiology is unknown.The disease may involve the digestive tract from the mouth to the anus,and the disease is easy to relapse,seriously affecting the quality of life of the patients.At present,the drugs used to treat CD are mainly amino salicylic acid preparations,glucocorticoids,immunosuppressive agents and biological agents.Drug therapy can effectively induce remission and improve clinical symptoms,but it lacks persistence.In recent years,there has been a gradual increase in the use of non-drug therapies for CD,including enteral nutrition(EN),fecal microbiota transplantation(FMT),mesenchymal stem cell transplantations(MSCs),and granulocyte and monocyte apheresis(GMA).This article mainly reviewed the research progress of these 4 non-drug therapies for CD.