硬化萎缩性苔藓的治疗进展

Advances of treatment in lichen sclerosus et atrophicus

硬化萎缩性苔藓(LSA)好发于女性,常见于外阴、躯干上部如胸背部等,反复发作可导致病损部位解剖结构改变、丧失生理功能,甚至诱发癌变。目前,LSA的发病机制尚未完全明确,临床上治疗方法有限,单一的药物治疗可能疗效不佳,而物理治疗尚缺乏大样本临床研究及远期随访。本文综述LSA的药物治疗和物理治疗方面的新进展。

Lichen sclerosus et atrophicus(LSA) is common in women, which tends to occur in vulva, upper trunk, such as the chest and back. Repeated attacks of the disease can lead to change in the anatomical structure, loss physiological function, and even induce canceration. At present, the pathogenesis of LSA is not completely clear, so the clinical treatment of LSA is limited, and a single drug treatment may not be effective. For example, some patients with LSA may be resistant to external hormones and present as refractory LSA, resulting in recurrent skin lesions, itching, pain and other symptoms. However, there is not still large-sample and long-term follow-up of physical therapy studies. This article reviews the recent advances of pharmacotherapy and physical therapy for LSA.