PCL基复合骨组织工程支架研究现状及发展

Polycaprolactone-Based Composite Scaffolds in Bone Tissue Engineering:Research Status and Prospect

三维骨组织工程支架已成为成骨研究领域的热点。聚己内酯(PCL)具有良好的生物相容性,在骨组织工程研究中被广泛应用于三维支架的制备。但纯PCL支架亲水性差、生物活性低,限制了其在生物医学领域的应用。随着骨组织工程材料研究的发展,大量研究者将PCL与各种无机物、金属元素或胶原等活性材料进行复合,以改善支架性能或引入新的性能。针对PCL基骨组织工程复合支架的材料选择,从PCL复合无机材料、PCL复合水凝胶材料、PCL复合金属元素、PCL复合小分子药物以及PCL复合生物活性分子等5个方面,对各类复合支架的性能及体内外成骨效果等方面进行综述,希望对PCL在骨组织工程中的研究及临床应用提供一定的帮助。

Three-dimensional scaffolds have received considerable attention in the field of bone tissue engineering.Polycaprolactone(PCL)is widely used in the preparation of 3 D scaffolds due to its good biocompatibility.However,pure PCL scaffolds have poor hydrophilicity and low biological activity,which limit their application in biomedical field.With the development of bone tissue engineering,a large number of investigations combined PCL with various inorganic substances,metal elements or natural collagen to improve the properties or introduce new properties into the PCL scaffolds.Based on the domestic and foreign literature,in this paper,the selection of materials for PCL bone tissue engineering composite scaffolds was summarized,including inorganic materials,hydrogel materials,metal elements,small molecule drugs and bioactive molecules.The properties and osteogenic effects of the various composite scaffolds were reviewed from five aspects,aiming to provide insights for the research and clinical application of PCL in the bone tissue engineering.