N6-甲基腺苷在肝细胞癌发生发展中的作用

Role of N6-methyladenosine in the development and progression of hepatocellular carcinoma

肝细胞癌是原发性肝癌中最为常见的一种类型,具有较高的发病率和死亡率。N6-甲基腺苷(m6A)的异常修饰将会促进肝细胞癌的发生与发展。叙述了m6A的结构与功能并总结了决定m6A功能的甲基化酶复合物,包括甲基转移酶(编辑器)、去甲基酶(消码器)和m6A结合蛋白(读码器)在肝细胞癌中的作用机制。认为需要更深入的研究阐明甲基化酶复合物在肝细胞癌中作用的多样性和特异性,以期使之成为预防和治疗肝细胞癌的新靶点。

Hepatocellular carcinoma(HCC)is the most common type of primary liver cancer and has relatively high incidence and mortality rates.Abnormal modification of N6-methyladenosine(m6A)may promote the development and progression of HCC.This article describes the structure and function of m6A and summarizes the mechanism of action of methylase complexes which decide the function of m6A in HCC,including methyltransferases(writers),demethylases(erasers),and m6A-binding proteins(readers).It is pointed out that more in-depth studies are needed to clarify the diverse and specific role of methylase complexes in HCC,so as to help them become the new targets for the prevention and treatment of HCC in the future.