自噬相关信号分子在非酒精性脂肪性肝病中的作用

Research advances in autophagy-related signal molecules in nonalcoholic fatty liver disease

非酒精性脂肪性肝病已成为世界范围内慢性肝病的主要原因之一,与代谢综合征关系密切。近年来,非酒精性脂肪性肝病的发病机制研究的越来越深入,其中,自噬是真核生物体内一个高度保守的过程,在非酒精性脂肪性肝病的疾病进展中起着至关重要的作用,有望成为治疗非酒精性脂肪性肝病的新靶标。就自噬相关信号分子在非酒精性脂肪性肝病中的研究进展进行综述,以期为治疗非酒精性脂肪性肝病提供新思路。

Nonalcoholic fatty liver disease(NAFLD)has become one of the main causes of chronic liver diseases worldwide and is closely associated with metabolic syndrome.In-depth studies on the pathogenesis of NAFLD in recent years have shown that autophagy is a highly conservative process in eukaryotes and plays an important role in the progression of NAFLD,and therefore,it is expected to become a new target for the treatment of NAFLD.This article reviews the research advances in autophagy-related signal molecules in NAFLD,in order to provide new ideas for the treatment of NAFLD.