靶向肿瘤微环境治疗胰腺癌的新进展

New advances in the treatment of pancreatic cancer by targeting tumor microenvironment

胰腺癌是5年生存率最低的消化道恶性肿瘤,现有的一线治疗方案并未明显改善患者总体预后,因此需要探索新的治疗方式。胰腺癌肿瘤微环境如基质屏障、免疫微环境、外泌体在促进胰腺癌细胞增殖、浸润、转移及放化疗抵抗中起到重要作用。总结了与胰腺癌肿瘤微环境相关的潜在靶点及其临床进展,以期为胰腺癌治疗提供新思考。

Pancreatic cancer is the malignant tumor of the digestive tract with the lowest 5-year survival rate,and current first-line treatment regimens cannot significantly improve the overall prognosis of patients,so it is necessary to explore new treatment methods.A large number of studies have shown that the tumor microenvironment of pancreatic cancer,such as stromal barrier,immune microenvironment,and exosomes,plays an important role in promoting the proliferation,invasion,metastasis,and chemoradiotherapy resistance of pancreatic cancer cells.This article summarizes the potential targets associated with the tumor microenvironment of pancreatic cancer and related clinical research advances,in order to provide new ideas for the treatment of pancreatic cancer.