摘要
中药是一个复杂的分子系统。如何全面、高效地分析中药成分是中药研究的难点。质谱分析技术,尤其是超高效/超高压液相色谱与高分辨质谱联用,具有高选择性、高灵敏和高质量精度的特点,是中药成分分析的有力手段。近年来,多功能杂化质谱带来的质谱数据采集新技术和数据处理新策略也在不断发展,如全信息串联质谱(MS^(E))技术、SWATH技术、质谱树状图相似度过滤技术(MTSF)和分子网络策略(MN)等,加快了中药成分分析过程。本文综述了质谱分析新技术和新策略在中药成分分析中的应用,包括色谱-质谱联用和离子淌度技术,以及质谱参数设置、采集模式和数据处理策略,并对其前景进行展望。
The composition of traditional Chinese medicine(TCM)is complex,and analysis of those chemical compositions is vital for the research of TCM.Mass spectrometric-based technologies,especially ultrahigh performance liquid chromatography-high resolution mass spectrometry(UHPLC-HRMS),are considered to be powerful techniques with the advantages of high sensitivity,high selectivity,rapidity,and high resolution.In recent years,approaches of MS data acquisition and data post-processing strategies were continuously evolving,including MS^(E),SWATH,mass spectral trees similarity filter(MTSF),and molecular networking(MN),facilitating the exploration and identification of TCM components.In this paper,the applications of mass spectrometric-based technologies and strategies for the analysis of TCM components would be discussed as well as a brief outlook on the perspectives of such technologies and strategies.
作者
马聪玉
生宁
李元元
王喆
张金兰
MA Cong-yu;SHENG Ning;LI Yuan-yuan;WANG Zhe;ZHANG Jin-lan(Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《质谱学报》
EI
CAS
CSCD
北大核心
2021年第5期709-717,I0005,共10页
Journal of Chinese Mass Spectrometry Society
关键词
中药
色谱-质谱联用技术
高分辨质谱
数据采集模式
数据处理策略
traditional Chinese medicine(TCM)
chromatography coupled to mass spectrometry
high-resolution mass spectrometry(HRMS)
data acquisition
data post-processing strategies