布地奈德联合沙美特罗替卡松治疗支气管哮喘患儿的效果及对PEF、FVC、FEV_(1)的影响

Effect of Budesonide Combined with Salmeterol Ticasone in the Treatment of Children with Bronchial Asthma and Its Effect on PEF,FVC and FEV_(1)

目的:探讨布地奈德联合沙美特罗替卡松治疗支气管哮喘患儿的效果及对PEF、FVC、FEV_(1)的影响。方法:选取2018年9月-2020年6月于本院接受治疗的支气管哮喘患儿104例。依据治疗方案的不同将患儿分为对照组和研究组,每组52例。对照组单用沙美特罗替卡松治疗,研究组对照组基础上采用布地奈德治疗。比较两组临床疗效、肺功能指标水平、哮喘症状缓解时间及不良反应发生情况。结果:研究组临床总有效率高于对照组,差异均有统计学意义(P<0.05)。干预后,研究组FVC、FEV_(1)、PEF水平均高于对照组,差异均有统计学意义(P<0.05)。研究组喘息、肺啰音、呼吸困难、咳嗽缓解时间均短于对照组,差异均有统计学意义(P<0.05)。研究组不良反应发生率为17.3%,与对照组的15.4%比较,差异无统计学意义(P>0.05)。结论:支气管哮喘患儿应用布地奈德联合沙美特罗替卡松方案治疗,可提升临床疗效,改善患儿肺功能指标水平,还能缩短临床症状缓解时间,且不会增加不良反应发生率,可考虑推广。

Objective:To investigate the effect of Budesonide combined with Salmeterol Ticasone in the treatment of children with bronchial asthma and the effect on PEF,FVC and FEV_(1).Method:A total of104 children with bronchial asthma who received treatment in our hospital from September 2018 to June 2020 were selected.Patients were divided into the control group and the study group according to different treatment regimens,52 cases in each group.The control group was treated with Salmeterol Ticasone alone,the study group was treated with Budesonide on the basis of the control group.The clinical efficacy,pulmonary function index level,asthma symptom remission time and the incidence of adverse reactions were compared between two groups.Result:The total clinical effective rate of the study group was higher than that of the control group,the difference was statistically significant (P<0.05).After intervention,the levels of FVC,FEV_(1) and PEF in the study group were higher than those in the control group,the differences were statistically significant (P<0.05).The relief times of wheezing,lung rales,dyspnea and cough in the study group were shorter than those in the control group,the differences were statistically significant (P<0.05).The incidence of adverse reactions in the study group was 17.3%,compared with 15.4% in the control group,there was no statistical significance (P>0.05).Conclusion:For children with bronchial asthma,the application of Budesonide combined with Salmeterol Ticasone can enhance the clinical efficacy,improve the level of pulmonary function indicators in children,and shorten the remission time of clinical symptoms without increasing the incidence of adverse reactions,it can be considered for promotion.