低分子肝素联合华法林抗凝治疗对肺栓塞患者症状缓解情况、血气指标改善情况的影响

Effect of Low Molecular Weight Heparin Combined with Warfarin Anticoagulant Therapy on Symptom Remission and Blood Gas Index Improvement in Patients with Pulmonary Embolism

目的:探讨低分子肝素联合华法林抗凝治疗对肺栓塞患者症状缓解情况、血气指标改善情况的影响。方法:选取2017年5月-2019年1月本院收治的63例肺栓塞患者为研究对象。将患者随机分为研究组32例和对照组31例。对照组给予低分子肝素治疗,研究组在对照组基础上联合华法林治疗。比较两组患者症状缓解情况、血气指标改善情况、生活质量评分、不良反应发生情况与肺功能改善情况。结果:研究组症状缓解率96.9%,高于对照组77.4%,差异有统计学意义(P<0.05)。治疗后,两组血气指标均较治疗前改善,且研究组血气指标均优于对照组,差异均有统计学意义(P<0.05)。研究组药物不良反应发生率为3.1%,低于对照组的22.6%,差异有统计学意义(P<0.05)。治疗后,研究组生活质量各维度评分均高于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组肺动脉压力、呼吸困难评估分数均低于对照组,差异均有统计学意义(P<0.05)。结论:低分子肝素联合华法林治疗肺栓塞患者的效果显著,可有效缓解患者各项临床症状,改善患者血气指标,有效提高患者生活质量,用药安全性较高,可在临床推广应用。

Objective:To investigate the effects of Low Molecular Weight Heparin combined with Warfarin anticoagulant therapy on symptom relief and blood gas index improvement in patients with pulmonary embolism.Method:A total of 63 patients with pulmonary embolism admitted to our hospital from May 2017 to January 2019 were selected as the research subjects.The patients were randomly divided into study group (n=32) and control group (n=31).The control group was treated with Low Molecular Weight Heparin and the study group was treated with Warfarin on the basis of the control group.The symptom remission,blood gas index improvement,quality of life score,the incidence of adverse reactions and pulmonary function improvement were compared between the two groups.Result:The symptom remission rate of the study group was 96.6%,higher than 77.4% of the control group,the difference was statistically significant (P<0.05).After treatment,the blood gas indexes in both groups were improved compared with before treatment,the blood gas indexes in the study group were better than those in the control group,the differences were statistically significant (P<0.05).The incidence of adverse drug reactions in the study group was 3.1%,lower than 22.6% in the control group,the difference was statistically significant (P<0.05).After treatment,the quality of life scores of the study group were higher than those of the control group,the differences were statistically significant (P<0.05).After treatment,the pulmonary arterial pressure and dyspnea scores in the study group were lower than those in the control group,the differences were statistically significant (P<0.05).Conclusion:Low Molecular Weight Heparin combined with Warfarin in the treatment of pulmonary embolism patients has significant effect,it can effectively alleviate the clinical symptoms of patients,improve the blood gas index of patients,effectively improve the quality of life of patients,medication safety is high,which can be promoted in clinical application.