高压氧治疗对脑小血管病患者血清急性时相反应蛋白及认知相关指标的影响研究

Effect of Hyperbaric Oxygen Therapy on Serum Acute Phase Response Protein and Cognitive Related Indexes in Patients with Cerebral Small Vessel Disease

目的:探讨高压氧治疗对脑小血管病患者血清急性时相反应蛋白及认知相关指标的影响。方法:选取2019年3月-2020年6月本院100例脑小血管病患者为研究对象,将其随机分为对照组与观察组,每组50例。对照组进行常规治疗,观察组在对照组基础上加用高压氧治疗。比较两组治疗前及治疗2、4周后的简易智能精神状态检查量表(mini-mental state examination,MMSE)评分、血清急性时相反应蛋白[超敏C反应蛋白(hs-CRP)、α1-酸性糖蛋白(α1-acid glycoprotein,AAG)、触珠蛋白(haptoglobin,HP)]、认知相关指标[同型半胱氨酸(Hcy)、髓鞘碱性蛋白(MBP)及β淀粉样蛋白1-40(Aβ1-40)及事件相关电位P300]。结果:治疗2、4周后,观察组MMSE评分均优于对照组(P<0.05)。治疗2、4周后,观察组hs-CRP、AAG、Hp、Hcy、MBP、Aβ1-40均低于对照组(P<0.05)。治疗2、4周后,观察组的事件相关电位P300均优于对照组(P<0.05)。结论:高压氧治疗可显著改善脑小血管病患者的血清急性时相反应蛋白及认知相关指标,在本类患者中的应用价值较高。

Objective:To investigate the effects of hyperbaric oxygen therapy on serum acute phase response protein and cognitive related indexes in patients with cerebral small vessel disease.Method:A total of 100 patients with cerebral small vessel disease in our hospital from March 2019 to June 2020 were selected as the research objects.They were randomly divided into control group and observation group,with 50 cases in each group.The control group received routine treatment,and the observation group was additively treated with hyperbaric oxygen therapy.The mini-mental state examination (MMSE) scores,serum acute phase reaction protein[hs-CRP,α1-acid glycoprotein (AAG),haptoglobin (HP)],cognitive related indexes[homocysteine (Hcy),myelin basic protein (MBP),amyloid β1-40 (Aβ1-40) and event-related potential P300]were compared between the two groups before treatment and after 2 and 4 weeks of treatment.Result:After 2 and 4 weeks of treatment,MMSE scores in observation group were better than those in control group (P<0.05).After 2 and 4 weeks of treatment,hs-CRP,AAG,HP,Hcy,MBP and Aβ1-40 in observation group were lower than those in control group (P<0.05).After 2 and 4 weeks of treatment,the event-related potential P300 of the observation group were better than those of the control group (P<0.05).Conclusion:Hyperbaric oxygen therapy can significantly improve the serum acute phase response protein and cognitive related indexes in patients with cerebral small vessel disease,which has high application value in this kind of patients.