摘要
目的:比较迷走神经刺激术(VNS)与胼胝体切开术(CC)对治疗药物难治性癫痫(DRE)的效果。方法:选取2015年1月-2020年1月本院收治的85例DRE患者,将其按照手术方式分为A组(n=41)和B组(n=44)。A组采用VNS治疗,B组采用CC治疗。比较两组手术指标、并发症发生情况,比较术后3、6个月的总有效率及术前和术后3、6个月的QOLIE-31评分。结果:A组手术时长、住院康复时间均短于B组,术中失血量少于B组,差异均有统计学意义(P<0.05)。两组术后3、6个月的总有效率比较,差异均无统计学意义(P>0.05)。两组术后血管损伤、神经损伤、术区感染以及尿失禁发生率比较,差异均无统计学意义(P>0.05)。术前,两组QOLIE-31评分比较,差异均无统计学意义(P>0.05);术后3、6个月,A组QOLIE-31评分均高于B组,差异均有统计学意义(P<0.05)。结论:VNS治疗DRE患者的术中失血量更少,对早日康复有积极促进作用,且并发症发生率无明显提高,可改善患者的生活质量。
Objective:To compare the influence of vagal nerve stimulation (VNS) and corpus callosotomy (CC) in the treatment of Drug-resistant epilepsy (DRE).Method:A total of 85 patients with DRE admitted to the hospital from January 2015 to January 2020 were selected,and they were divided into group A (n=41) and group B (n=44) according to surgical treatment methods.The group A was treated with VNS treatment,while the group B was treated with CC treatment.The surgical indicators and the incidence of complications were compared between two groups,the total effective rate 3 and 6 months after surgery and the QOLIE-31 score before and 3 and 6 months after surgery were compared between two groups.Result:The surgical duration and hospitalization recovery time of the group A were shorter than that of the group B,and the intraoperative blood loss of the group A was less than that of the group B,the differences were statistically significant (P<0.05).3 and 6 months after surgery,there were no significant differences in the total effective rates between two groups (P>0.05).There were no significant differences in the incidences of postoperative vascular injury,nerve injury,operative area infection and urinary incontinence between two groups (P>0.05).Before surgery,there was no significant difference in QOLIE-31 scores between two groups (P>0.05).3 and 6 months after surgery,QOLIE-31 scores of the group A were higher than those of the group B,the differences were statistically significant (P<0.05).Conclusion:VNS treatment of DRE patients with less intraoperative blood loss,has a positive role in promoting early recovery,and the incidence of complications did not significantly increase,can improve the quality of life of patients.
作者
朱鹏飞
ZHU Pengfei(Qinghe District Hospital of Tieling City,Tieling 112003,China)
出处
《中国医学创新》
CAS
2021年第22期135-138,共4页
Medical Innovation of China