小剂量阿司匹林对妊娠期高血压疾病患者微循环及血液流变学的影响研究

Study on the Influence of Low-dose Aspirin for Microcirculation and Hemorheology of Patients with Gestational Hypertension

目的:探究小剂量阿司匹林对妊娠期高血压疾病患者微循环及血液流变学的影响。方法:选取2018年6月-2020年5月100例妊娠期高血压疾病患者,依据随机数字表法将其分为对照组和观察组,每组50例。对照组采用常规治疗,观察组在对照组的基础上加用小剂量阿司匹林。比较两组的临床疗效、甲襞微循环加权积分(襻周、形态、流态积分)、其他相关指标(白微栓率、管襻畸形率、管襻数目)及血液流变学指标(全血高切黏度、全血低切黏度、血浆黏度)。结果:治疗4、8周,观察组的总有效率均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组襻周、形态、流态积分、白微栓率、管襻畸形率、管襻数目比较,差异无统计学意义(P>0.05);治疗4、8周后,观察组襻周、形态、流态积分、白微栓率、管襻畸形率均低于对照组,管襻数目均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组全血高切黏度、全血低切黏度、血浆黏度比较,差异均无统计学意义(P>0.05);治疗4、8周,观察组全血高切黏度、全血低切黏度、血浆黏度均低于对照组,差异均有统计学意义(P<0.05)。结论:小剂量阿司匹林在妊娠期高血压疾病患者中的应用效果较好,可改善患者的微循环及血液流变学指标,在妊娠期高血压疾病患者中的应用价值较高。

Objective:To investigate the influence of low-dose Aspirin for microcirculation and hemorheology of patients with gestational hypertension.Method:A total of 100 patients with gestational hypertension from June 2018 to May 2020 were selected,and they were randomly divided into control group and observation group according to the random number table method,50 cases in each group.The control group was treated with routine treatment,and the observation group was treated with low-dose Aspirin on the basis of control group.The clinical efficacy,nail fold microcirculation weighted integral score (circumference,morphology,flow integral scores),other related indexes (white microemboli rate,malformation rate of the tube loops and number of the tube loops) and hemorheology indexes (whole blood high-cut viscosity,whole blood low-cut viscosity and plasma viscosity) were compared between two groups.Result:After 4 and 8 weeks of treatment,the total effective rates of the observation group were higher than those of the control group,the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in the circumference,morphology,flow integral scores,white microemboli rate,malformation rate of the tube loops and number of the tube loops between two groups (P>0.05);after 4 and 8 weeks of treatment,the circumference,morphology,flow integral scores,white microemboli rate and malformation rate of tube loops of the observation group were lower than those of the control group,and the number of the tube loops was higher than that of the control group,the differences were statistically significant (P<0.05).Before treatment,there were no significant differences in whole blood high-cut viscosity,whole blood low-cut viscosity and plasma viscosity between two groups (P>0.05);after 4 and 8 weeks of treatment,the whole blood high-cut viscosity,whole blood low-cut viscosity and plasma viscosity of the observation group were lower than those of the control group,the differences were statistically significant (P<0.05).Conclusion:The effect of low-dose Aspirin in the patients with gestational hypertension is better,and it can improve the microcirculation and hemorheology indexes,so its application value in the patients with gestational hypertension is higher.