完全腹膜外补片植入术治疗对腹股沟疝患者血清hs-CRP、TNF-α、IL-6水平的影响

Effect of Totally Extraperitoneal Prosthetic on Serum hs-CRP,TNF-α and IL-6 Levels in Patients with Inguinal Hernia

目的:探讨完全腹膜外补片植入术(TEP)治疗对腹股沟疝患者血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平的影响。方法:选取2019年1-7月于本院确诊并治疗的110例腹股沟疝患者,依据治疗方式不同将其分成对照组与研究组,每组55例。对照组采用Millikan术式治疗,研究组采用TEP治疗。比较两组手术时长及康复指标(首次下床活动时间、疼痛持续时间、能够自由活动时间及使用止疼药次数);比较两组并发症发生情况;比较两组治疗前后相关炎症因子指标(hs-CRP、TNF-α、IL-6)。结果:研究组手术时长、首次下床活动时间、疼痛持续时间、能够自由活动时间均短于对照组,且研究组使用止疼药次数少于对照组(P<0.05)。研究组并发症发生率低于对照组(P<0.05)。治疗后,两组各项相关炎症因子指标水平均高于治疗前,但研究组均低于对照组(P<0.05)。结论:TEP治疗腹股沟疝患者可减轻手术创伤,促进患者康复,减少并发症,同时能够有效降低患者hs-CRP、TNF-α、IL-6水平。

Objective:To investigate the effect of totally extraperitoneal prosthetic (TEP) on serum hypersensitive C-reactive protein (hs-CRP),tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels in patients with inguinal hernia.Method:A total of 110 patients with inguinal hernia diagnosed and treated in our hospital from January to July 2019 were selected.They were divided into control group and study group according to different treatment methods,with 55 cases in each group.The control group was treated with Millikan operation,and the study group was treated with TEP.The duration of operation and recovery indicators (first time of getting out of bed,duration of pain,time of free movement and times of painkiller use) were compared between the two groups.The incidence of complications was compared between the two groups.The related inflammatory factors (hs-CRP,TNF-α,IL-6) were compared between the two groups before and after treatment.Result:The duration of operation,the first time of getting out of bed,duration of pain,time of free movement in the study group were all shorter than those in the control group,and the times of painkiller use in the study group was less than that in the control group (P<0.05).The complication rate in the study group was lower than that in the control group (P<0.05).After treatment,the levels of all related inflammatory factors in both groups were higher than those of before treatment,but those in the study group were lower than those in the control group (P<0.05).Conclusion:The treatment of inguinal hernia patients with TEP can reduce surgical trauma,promote patient recovery,reduce complications,and effectively reduce the level of hs-CRP、TNF-α、IL-6 in patients.