miR-22、NLRP3、PI3K/AKT信号通路在卵巢癌中作用研究进展

Research Progress on the Role of miR-22,NLRP3 and PI3K/Akt Signaling Pathway in Ovarian Cancer

卵巢癌是女性最致命的恶性肿瘤,有多种信号通路参与其的形成。PI3K/AKT通路可调控细胞内一系列重要的生物学活动,包括细胞的生长,增殖,转录等,该信号通路异常往往导致细胞异常增殖、肿瘤转移以及产生耐药性等重要生物过程的改变。miR-22通过靶向NLRP3抑制PI3K/AKT信号通路。本文将miR-22、NLRP3在卵巢癌中影响PI3K/AKT信号通路的研究进展做一综述,为卵巢癌的靶向治疗提供新的方向和思路。

Ovarian cancer is the most deadly malignant tumor in women,and multiple signaling pathways are involved in its formation.PI3K/AKT pathway can regulate a series of important biological activities in cells,including cell growth,proliferation,transcription,etc.Abnormal signaling pathway often leads to changes in important biological processes such as abnormal cell proliferation,tumor metastasis and drug resistance.miR-22 inhibits the PI3K/AKT signaling pathway by targeting NLRP3.This paper reviews the research progress of miR-22 and NLRP3 affecting PI3K / Akt signaling pathway in ovarian cancer,so as to provide new directions and ideas for targeted therapy of ovarian cancer.