注射用替考拉宁致精神异常1例分析

Psychosis Induced by Teicoplanin:A Case Report

目的分析替考拉宁致精神异常1例,提示临床重视替考拉宁所致的药品不良反应。方法分析1例使用替考拉宁治疗耐甲氧西林金黄色葡萄球菌(MRSA)感染时出现精神异常患者的诊疗经过,通过文献分析,阐述替考拉宁诱发精神异常的主要原因。结果本例患者出现精神异常很可能是替考拉宁所致。结论替考拉宁的血药浓度在重症及合并低蛋白血症患者中变异性较大,治疗上应根据患者体重及白蛋白情况予以适宜的剂量,避免血药浓度过高出现相关不良反应。

Objective To analyze one case of psychosis induced by teicoplanin in order to call clinical attention to adverse reactions caused by teicoplanin.Methods The process of diagnosis and treatment of a patient with mental disorder in the course of treatment of methicillin-resistant Staphylococcus aureus(MRSA)infection with teicoplanin was analyzed.Through literature review and analysis,the main causes of mental disorder induced by teicoplanin were described.Results This case of psychosis was likely induced by teicoplanin.Conclusion The concentration of teicoplanin among critically ill patients,especially those with hypoalbuminemia,is highly variable.An appropriate dose should be given on the basis of the patient’s weight and albumin so that the adverse reactions caused by high blood concentration could be prevented.