吸入用复方异丙托溴铵溶液致幼儿急性颜面部皮疹伴肿胀1例分析

Acute Skin Rash and Swelling Induced by Compound Ipratropium Bromide Solution for Inhalation:A Case Report

目的分析吸入用复方异丙托溴铵溶液致颜面部皮疹伴肿胀的不良反应,为临床安全用药提供参考。方法报道1例支气管肺炎患儿在药物治疗期间发生唇周皮疹、面颊及双唇发红肿胀的不良事件,并通过病例回顾性分析及不良反应关联性评价分析其原因。结果该不良事件为雾化吸入复方异丙托溴铵溶液所引起的药物不良反应,及时合理处置后能有效控制消散。结论关于幼儿使用吸入用复方异丙托溴铵溶液引起的不良反应较少,速发型的皮疹伴肿胀更是罕见,在临床应用中需多加关注,保障儿童用药安全。

Objective To analyze the adverse drug reactions(ADR)induced by the compound ipratropium bromide solution for inhalation in order to provide reference for safe clinical use of drugs.Methods One case of a baby with bronchopneumonia who developed skin rash around his lips during treatment was reported.The baby's face and lips turned red and swollen.The cause of these symptoms was explored via retrospective analysis and correlation analysis of ADR.Results It was found that the above symptoms were ADR induced by the ipratropium bromide solution for inhalation,which could be effectively ameliorated with proper treatment.Conclusion ADR among babies caused by the ipratropium bromide solution for inhalation are seldom reported,and immediate skin rash is quite rare.Such ADR deserve more attention in clinical practice to ensure safe use of drugs among young babies.