核苷(酸)类似物抗病毒治疗慢性乙型肝炎患者的临床效果及对其HBV DNA转阴率的影响

Clinical Effect of Antiviral Treatment with Nucleoside (acid) Analogue on Patients with Chronic Hepatitis B and Its Effect on HBV DNA Negative Conversion Rate

目的:探究核苷(酸)类似物抗病毒治疗慢性乙型肝炎患者的临床效果及对其HBV DNA转阴率的影响。方法:选取2017年4月-2019年8月本院收治的58例慢性乙型肝炎患者。根据治疗方式的不同分成对照组和研究组,每组29例。对照组给予常规治疗,研究组采用核苷(酸)类似物抗病毒治疗。比较两组临床治疗效果、HBV DNA转阴率与HBeAg转阴率、相关肝功能指标以及相关肝肌纤维化指标。结果:研究组总有效率为93.1%,高于对照组的72.4%,差异有统计学意义(P<0.05)。研究组HBV DNA转阴率、HBeAg转阴率均高于对照组,差异均有统计学意义(P<0.05)。治疗前,两组肝肌纤维化相关指标、肝功能相关指标比较,差异均无统计学意义(P>0.05);治疗后,两组肝肌纤维化相关指标、肝功能相关指标均较治疗前改善,且研究组均优于对照组,差异均有统计学意义(P<0.05)。结论:应用核苷(酸)类似物抗病毒治疗慢性乙型肝炎患者临床效果显著,患者HBV DNA转阴率提高,肝肌纤维化及正常肝功能得到改善,可在临床应用并推广。

Objective:To explore the clinical effect of antiviral treatment with nucleoside (acid) analogue on patients with chronic hepatitis B and its effect on HBV DNA negative conversion rate.Method:A total of58 patients with chronic hepatitis B admitted to our hospital from April 2017 to August 2019 were selected.According to different treatment methods,they were divided into control group and study group,29 cases in each group.The control group received conventional treatment,the study group received antiviral treatment with nucleoside (acid) analogues.The clinical treatment effect,HBV DNA negative conversion rate and HBeAg negative conversion rate,related liver function indexes and related hepatic muscle fibrosis indexes were compared between two groups.Result:The total effective rate of the study group was 93.1%,which was higher than 72.4% of the control group,the difference was statistically significant (P<0.05).The HBV DNA negative rate and HBeAg negative rate in the study group were higher than those in the control group,the differences were statistically significant (P<0.05).Before treatment,comparison of hepatic muscle fibrosis and liver function related indexes between two groups,there were no significant differences (P>0.05).After treatment,indexes related to hepatic muscle fibrosis and liver function in both groups were improved compared with those before treatment,and the study group were better than those in the control group,the differences were statistically significant (P<0.05).Conclusion:The antiviral treatment with nucleoside (acid) analogue of chronic hepatitis B patients has a significant clinical effect,HBV DNA negative rate,hepatic muscle fibrosis and normal liver function can be improved,which can be applied and promoted in clinical practice.