多西他赛联合长春酰胺治疗卵巢癌的效果及对机体免疫力、QOL评分的影响

Effect of Docetaxel Combined with Vinblastine in the Treatment of Ovarian Cancer and Its Influence on Immunity and QOL Score

目的:探究多西他赛联合长春酰胺治疗卵巢癌的效果及对机体免疫力、QOL评分的影响。方法:选取2017年3月-2020年3月本院收治的94例卵巢癌患者,随机分为两组,每组47例。对照组应用多西他赛治疗,研究组在对照组基础上应用长春酰胺治疗。比较两组治疗效果、BDNF、5-HT水平、QOL评分、卵巢功能、免疫指标、焦虑与抑郁评分。结果:与对照组比较,研究组治疗总有效率更高(P<0.05)。两组治疗前BDNF、5-HT水平比较,差异均无统计学意义(P>0.05);研究组治疗后BDNF、5-HT水平均高于对照组(P<0.05)。两组治疗前各项QOL评分比较,差异均无统计学意义(P>0.05);研究组治疗后各项QOL评分均高于对照组(P<0.05)。两组治疗前卵巢功能对比,差异均无统计学意义(P>0.05);研究组治疗后LH、FSH水平均高于对照组,E2水平低于对照组,差异均有统计学意义(P<0.05)。两组治疗前免疫指标比较,差异均无统计学意义(P>0.05);两组治疗前免疫指标比较,差异均无统计学意义(P>0.05);与对照组比较,治疗后研究组CD8^(+)水平更高,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均更低(P<0.05)。两组治疗前焦虑、抑郁评分比较,差异均无统计学意义(P>0.05);治疗后,研究组焦虑、抑郁评分均低于对照组(P<0.05)。结论:卵巢癌采用多西他赛联合长春酰胺治疗,效果显著,可维持正常BDNF、5-HT水平,提高生活质量,改善免疫和卵巢功能,改善不良情绪,有利于病情恢复。该治疗方法应在临床上广泛应用。

Objective:To explore the effect of Docetaxel combined with Vinblastine in the treatment of ovarian cancer and its influence on immunity and QOL score.Method:A total of 94 patients with ovarian cancer in our hospital from March 2017 to March 2020 were selected and randomly divided into two groups,47 cases in each group.The control group was treated with Docetaxel,and the study group was treated with Vinblastine on the basis of the control group.The treatment effect,BDNF,5-HT level,quality of life,ovarian function,immune index,anxiety and depression score were compared between two groups.Result:Compared with the control group,the total effective rate of the study group was higher (P<0.05).There were no significant differences in the levels of BDNF and 5-HT between two groups before treatment (P>0.05).The levels of BDNF and 5-HT in the study group after treatment were higher than those in the control group (P<0.05).There were no significant differences in all QOL scores between two groups before treatment (P>0.05).The all QOL scores in the study group after treatment were higher than those in the control group (P<0.05).There were no significant differences in ovarian function between two groups before treatment (P>0.05).After treatment,the levels of LH and FSH in the study group were higher than those in the control group,and the level of E2 was lower than that in the control group (P<0.05).There were no significant differences in immune indexes between two groups before treatment (P>0.05).Compared with the control group,the level of CD8+ in the study group after treatment was higher,and the levels of CD3+,CD4+,CD4+/CD8+ were lower (P<0.05).There were no significant differences in anxiety and depression scores between two groups before treatment (P>0.05).After treatment,the scores of anxiety and depression in the study group were lower than those in the control group (P<0.05).Conclusion:Docetaxel combined with Vinorelbine in the treatment of ovarian cancer,the effect is significant,it can maintain normal BDNF and 5-HT levels,improve the quality of life,improve immune and ovarian function,improve bad mood.It is conducive to the recovery of the disease,the treatment should be widely used in clinical practice.