血清胰岛素样生长因子Ⅰ在乙型肝炎肝硬化患者中的表达及与胃肠屏障功能指标的相关性分析

Expression of Serum Insulin-like Growth Factor Ⅰ in Patients with Hepatitis B and Liver Cirrhosis and Its Correlation with Gastrointestinal Barrier Function

目的:探讨血清胰岛素样生长因子Ⅰ在乙型肝炎肝硬化患者中的表达及与胃肠屏障功能指标的相关性。方法:选择2018年4月-2020年1月本院收治的乙型肝炎肝硬化患者84例为观察组,选择同期健康体检者71例为对照组。根据肝功能Child-Pugh分级将观察组分为A级组(n=37)、B级组(n=24)及C级组(n=23)。比较观察组和对照组IGF-Ⅰ及胃肠屏障功能指标,比较观察组不同肝功能分级患者IGF-Ⅰ及胃肠屏障功能指标,分析乙型肝炎肝硬化患者IGF-Ⅰ水平与胃肠屏障功能指标的相关性。结果:观察组IGF-Ⅰ水平低于对照组,DAO、D乳酸、内毒素及L/M水平均高于对照组,差异均有统计学意义(P<0.05)。A级组IGF-Ⅰ水平高于B、C级组,DAO、D乳酸、内毒素及L/M水平均低于B、C级组,差异均有统计学意义(P<0.05);B级组IGF-Ⅰ水平高于C级组,DAO、D乳酸、内毒素及L/M水平均低于C级组,差异均有统计学意义(P<0.05)。相关性分析结果显示,乙型肝炎肝硬化患者IGF-Ⅰ水平与DAO、D-乳酸、内毒素、L/M均呈负相关性(P<0.05)。结论:IGF-Ⅰ在乙型肝炎肝硬化患者中呈高表达,其表达水平能反映患者的疾病严重程度,且与肠道屏障功能存在相关性,参与肠道屏障功能损害。

Objective:To investigate the expression of serum insulin-like growth factor Ⅰ (IGF-Ⅰ) in patients with hepatitis B and liver cirrhosis and its correlation with gastrointestinal barrier function.Method:A total of 84 patients with hepatitis B cirrhosis admitted to our hospital from April 2018 to January 2020 were selected as the observation group,and 71 healthy patients were selected as the control group.The observation group was divided into grade A group (n=37),grade B group (n=24) and grade C group (n=23) according to Child-Pugh grading of liver function.IGF-Ⅰ and gastrointestinal barrier function indexes were compared between the observation group and the control group,IGF-Ⅰ and gastrointestinal barrier function indexes were compared in patients with different liver function grades in the observation group,the correlation between IGF-Ⅰ level and gastrointestinal barrier function indexes in patients with hepatitis B cirrhosis were analyzed.Result:The levels of IGF-Ⅰ in the observation group was lower than that in the control group,the levels of DAO,D-lactic acid,endotoxin and L/M in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).The levels of IGF-Ⅰ in grade A group were higher than those in grade B group and grade C group,the levels of DAO,D-lactic acid,endotoxin and L/M in grade A group were lower than those in grade B group and grade C group,the differences were statistically significant (P<0.05).The level of IGF-Ⅰ in grade B group was higher than that in grade C group,the levels of DAO,D-lactic acid,endotoxin and L/M were lower than those in grade C group,the differences were statistically significant (P<0.05).The results of correlation analysis showed that the level of IGF-Ⅰ was negatively correlated with DAO,D-lactic acid,endotoxin and L/M (P<0.05).Conclusion:IGF-Ⅰ is highly expressed in patients with hepatitis B cirrhosis,and its expression level can reflect the severity of the disease,and is correlated with intestinal barrier function,and can participate in the impairment of intestinal barrier function.