摘要
围手术期患者出现疼痛较常见,疼痛可引起一系列不良反应,对围手术期麻醉及术后康复的相关管理产生负面影响。而完善的围手术期镇痛可以有效减轻患者应激反应,促进患者术后康复。羟考酮通过激动μ、κ双阿片受体产生镇痛作用,与吗啡的镇痛效果相当且不良反应较少,因此目前广泛应用于临床,尤其对内脏痛有特异性的作用。同时,羟考酮可维持或提高机体的免疫功能,对机体具有较好的保护作用,但其影响免疫功能的具体作用机制目前尚不明确。目前关于羟考酮硬膜外给药的相关临床研究较少,仍需未来大量研究证实其安全性和有效性。
Pain is very common in patients during the perioperative period, which often causes a series of adverse reactions and has a great negative impact on the related management of perioperative anesthesia and postoperative rehabilitation.Perfect perioperative analgesia can effectively reduce the perioperative stress response and promote postoperative recovery of the patients.Oxycodone has an analgesic effect by stimulating the μ and κ opioid receptors, which has an analgesic effect equivalent to that of morphine but fewer adverse reactions, and is widely used in clinical practice, with specific effect especially for visceral pain.At the same time, oxycodone can maintain or improve the immune function and has a good protective effect on the body.However, the specific mechanism of its effect on immune function is still unclear.At present, there are few clinical studies related to epidural administration of oxycodone, and a large number of future studies are needed to confirm its safety and effectiveness.
作者
彭山攀
谢海辉
PENG Shanpan;XIE Haihui(Guangdong Medical University,Zhanjiang 524000,China;Department of Anesthesiology,Dongguan People′s Hospital,Dongguan 523000,China)
出处
《医学综述》
CAS
2021年第17期3478-3482,共5页
Medical Recapitulate
基金
广东省医学科学技术研究基金项目(C2018055)。
关键词
羟考酮
内脏痛
镇痛
免疫
Oxycodone
Visceral pain
Analgesia
Immune
